| MRI and cognition in multiple sclerosis. | |
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MedLine Citation:
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PMID: 20635114 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Magnetic resonance imaging (MRI) techniques have contributed to ameliorate the understanding of the mechanisms responsible for the accumulation of cognitive impairment in patients with multiple sclerosis. Earlier studies demonstrated a relationship of the location of T2-visible lesions in critical brain regions and atrophy of several brain compartments with the severity of cognitive impairment in these patients. More recently, the development of new postprocessing approaches and the application of quantitative MR techniques for the assessment of structural disease-related damage in the brain normal-appearing white matter and gray matter resulted in a better understanding of the factors associated with the onset and development of deficits of several cognitive domains. In addition, the use of functional MRI has disclosed that brain cortical reorganization may play a role in limiting the neuropsychological consequences of structural damage in the different stages of the disease. |
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Authors:
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M Filippi; M A Rocca |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology Volume: 31 ISSN: 1590-3478 ISO Abbreviation: Neurol. Sci. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100959175 Medline TA: Neurol Sci Country: Italy |
Other Details:
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Languages: eng Pagination: S231-4 Citation Subset: IM |
Affiliation:
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Division of Neuroscience, Institute of Experimental Neurology, Scientific Institute and University Hospital San Raffaele, Milan, Italy. m.filippi@hsr.it |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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