| MRI of blood flow of the human retina. | |
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MedLine Citation:
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PMID: 21590806 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study reports a high-resolution MRI approach to image basal blood flow and hypercapnia-induced blood-flow changes in the unanesthetized human retina on a 3-T MRI scanner. Pseudocontinuous arterial spin labeling technique with static tissue suppression was implemented to minimize movement artifacts and improve blood-flow sensitivity. Turbo spin-echo acquisition was used to achieve high spatial resolution free of susceptibility artifacts. The size, shape, and position of a custom-made receive radiofrequency coil were optimized for sensitivity in the posterior retina. Synchronized eye blink and respiration to the end of each data readout minimized eye movement and physiological fluctuation. Robust high-contrast blood-flow MRI of the unanesthetized human retina was obtained at 500 × 800 μm(2) in-plane resolution. Blood flow in the posterior retina was 93 ± 31 mL/(100 mL min) (mean ± standard deviation, N = 5). Hypercapnic inhalation (5% CO(2)) increased blood flow by 12 ± 4% relative to air (P < 0.01, N = 5). This study demonstrates the feasibility of blood-flow MRI of the retina of unanesthetized human. Because blood flow is tightly coupled to metabolic function under normal conditions and it is often perturbed in diseases, this approach could provide unique insights into retinal physiology and serve as an objective imaging biomarker for disease staging and testing of novel therapeutic strategies. This approach could open up new avenue of retinal research. |
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Authors:
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Qi Peng; Yi Zhang; Oscar San Emeterio Nateras; Matthias J P van Osch; Timothy Q Duong |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2011-02-24 |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 65 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-18 Completed Date: 2011-09-22 Revised Date: 2011-10-21 |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 1768-75 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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Research Imaging Institute, University of Texas Health Science Center, San Antonio, Texas 78229, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Algorithms Artifacts Feasibility Studies Female Humans Magnetic Resonance Imaging / methods* Male Middle Aged Regional Blood Flow Retinal Vessels / anatomy & histology* Sensitivity and Specificity Spin Labels |
| Grant Support | |
ID/Acronym/Agency:
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EY018855/EY/NEI NIH HHS; R01 EY014211/EY/NEI NIH HHS; R01 EY014211-10/EY/NEI NIH HHS; R01 EY018855-04/EY/NEI NIH HHS; UL1RR025767/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Spin Labels |
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