Document Detail


MRI-based quantification of outflow boundary conditions for computational fluid dynamics of stenosed human carotid arteries.
MedLine Citation:
PMID:  20627249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Accurate assessment of wall shear stress (WSS) is vital for studies on the pathogenesis of atherosclerosis. WSS distributions can be obtained by computational fluid dynamics (CFD) using patient-specific geometries and flow measurements. If patient-specific flow measurements are unavailable, in- and outflow have to be estimated, for instance by using Murray's Law. It is currently unknown to what extent this law holds for carotid bifurcations, especially in cases where stenoses are involved. We performed flow measurements in the carotid bifurcation using phase-contrast MRI in patients with varying degrees of stenosis. An empirical relation between outflow and degree of area stenosis was determined and the outflow measurements were compared to estimations based on Murray's Law. Furthermore, the influence of outflow conditions on the WSS distribution was studied. For bifurcations with an area stenosis smaller than 65%, the outflow ratio of the internal carotid artery (ICA) to the common carotid artery (CCA) was 0.62+/-0.12 while the outflow ratio of the external carotid artery (ECA) was 0.35+/-0.13. If the area stenosis was larger than 65%, the flow to the ICA decreased linearly to zero at 100% area stenosis. The empirical relation fitted the flow data well (R(2)=0.69), whereas Murray's Law overestimated the flow to the ICA substantially for larger stenosis, resulting in an overestimation of the WSS. If patient-specific flow measurements of the carotid bifurcation are unavailable, estimation of the outflow ratio by the presented empirical relation will result in a good approximation of calculated WSS using CFD.
Authors:
Harald C Groen; Lenette Simons; Quirijn J A van den Bouwhuijsen; E Marielle H Bosboom; Frank J H Gijsen; Alina G van der Giessen; Frans N van de Vosse; Albert Hofman; Antonius F W van der Steen; Jacqueline C M Witteman; Aad van der Lugt; Jolanda J Wentzel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomechanics     Volume:  43     ISSN:  1873-2380     ISO Abbreviation:  J Biomech     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-16     Completed Date:  2010-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0157375     Medline TA:  J Biomech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2332-8     Citation Subset:  IM    
Copyright Information:
2010 Elsevier Ltd. All rights reserved.
Affiliation:
Biomechanics Laboratory, Biomedical Engineering, EE2322, Erasmus MC, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Aged
Biomechanics
Blood Flow Velocity
Carotid Artery, Common / pathology,  physiopathology
Carotid Artery, External / pathology,  physiopathology
Carotid Artery, Internal / pathology,  physiopathology
Carotid Stenosis / pathology*,  physiopathology*
Humans
Hydrodynamics
Imaging, Three-Dimensional
Magnetic Resonance Angiography
Models, Cardiovascular
Prospective Studies
Regional Blood Flow

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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