| MRI analysis in temporal lobe epilepsy: Cortical thinning and white matter disruptions are related to side of seizure onset. | |
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MedLine Citation:
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PMID: 21972957 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Purpose: Past studies reported more widespread structural brain abnormalities in patients with left compared to right temporal lobe epilepsy (TLE), but the profile of these differences remains unknown. This study investigated the relationship between cortical thinning, white matter compromise, epilepsy variables, and the side of seizure onset, in patients with TLE. Methods: We performed diffusion tensor imaging tractography and cortical thickness analyses of 18 patients with left TLE (LTLE), 18 patients with right TLE (RTLE), and 36 controls. We investigated the relationship among brain structural abnormalities, side of seizure onset, age of seizure onset, and disease duration. Key Findings: Patients with TLE displayed cortical thinning and white matter compromise, predominately on the side ipsilateral to the seizure onset. Relative to RTLE, patients with LTLE showed more widespread abnormalities, particularly in white matter fiber tracts. Greater compromise in white matter integrity was associated with earlier age of seizure onset, whereas cortical thinning was marginally associated with disease duration. Significance: These data support previous findings of LTLE showing greater structural compromise than RTLE, and suggest that mechanisms may not be uniform for gray and white matter compromise in patients with LTLE and RTLE. These results may indicate that LTLE is different from RTLE, possibly due to greater vulnerability of the left hemisphere to early injury and the progressive effects of seizures. |
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Authors:
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Nobuko Kemmotsu; Holly M Girard; Boris C Bernhardt; Leonardo Bonilha; Jack J Lin; Evelyn S Tecoma; Vicente J Iragui; Donald J Hagler; Eric Halgren; Carrie R McDonald |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-5 |
Journal Detail:
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Title: Epilepsia Volume: - ISSN: 1528-1167 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Wiley Periodicals, Inc. © 2011 International League Against Epilepsy. |
Affiliation:
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Department of Psychiatry, University of California, San Diego, California, U.S.A. Multimodal Imaging Laboratory, University of California, San Diego, California, U.S.A. Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada Department of Social Neuroscience, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany Division of Neurology Medical University of South Carolina, Charleston, South Carolina, U.S.A. Department of Neurology, University of California, Irvine, California, U.S.A. Department of Neurosciences, University of California, San Diego, California, U.S.A. Department of Radiology, University of California, San Diego, California, U.S.A. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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