| MRI Studies of the Hydrodynamics in a USP 4 Dissolution Testing Cell. | |
| | |
MedLine Citation:
|
PMID: 20949631 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
We present a detailed study of hydrodynamics inside the flow-through dissolution apparatus when operated according to USP recommendations. The pulsatile flow inside the flow-through cell was measured quantitatively using magnetic resonance imaging (MRI) at a spatial resolution of 234 × 234 μm(2) and slice thickness of 1 mm. We report the experimental protocols developed for in situ MRI studies and the effect that the operating conditions and tablet orientation have on the hydrodynamics inside commercial flow cells. It was found that the flow field inside the dissolution cells was, at most operating conditions, heterogeneous, rather than fully developed laminar flow, and characterised by re-circulation and backward flow. A model tablet was shown to be contacted by a wide distribution of local velocities as a function of position and orientation in the flow cell. The use of 1 mm beads acted as a distributor of the flow but did not suffice to ensure a fully developed laminar flow profile. These results emphasise the necessity to understand the influence of test conditions on dissolution behaviour in defining robust flow-through dissolution methods. © 2010 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 100:976-991, 2011. |
| | |
Authors:
|
G Shiko; L F Gladden; A J Sederman; P C Connolly; J M Butler |
Publication Detail:
|
Type: Journal Article Date: 2010-10-14 |
Journal Detail:
|
Title: Journal of pharmaceutical sciences Volume: 100 ISSN: 1520-6017 ISO Abbreviation: J Pharm Sci Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-01-31 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: United States |
Other Details:
|
Languages: eng Pagination: 976-91 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Wiley-Liss, Inc. |
Affiliation:
|
Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 3RA, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Frameshift mutations in dentin phosphoprotein and dependence of dentin disease phenotype on mutation...
Next Document: Smoothing molecular interactions: the "kinetic buffer" effect of intrinsically disordered proteins.