| Photo essay. MRI and positron emission tomography findings in Heidenhain variant Creutzfeldt-Jakob disease. | |
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MedLine Citation:
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PMID: 20581692 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The typical presentation of Heidenhain variant Creutzfeldt-Jakob disease (CJD) is a rapidly progressive visual loss in the setting of a relatively normal ophthalmologic examination. At presentation, patients with this uniformly fatal illness frequently demonstrate only minor cortical abnormalities on MRI. Here, we document the clinical presentation and imaging results of a patient with Heidenhain variant CJD in whom abnormalities on positron emission tomographic imaging were more evident than changes on MRI. These changes were present in striate cortex and visual association areas, providing clinical-anatomical correlation with our patient's visual deficits. Nuclear imaging provides a considerably more sensitive measure of neural dysfunction early in the course of this disease. |
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Authors:
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Sashank Prasad; Edward B Lee; John H Woo; Abass Alavi; Steven L Galetta |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society Volume: 30 ISSN: 1536-5166 ISO Abbreviation: J Neuroophthalmol Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-06 Completed Date: 2010-12-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9431308 Medline TA: J Neuroophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 260-2 Citation Subset: IM |
Affiliation:
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Departments of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA. sashank.prasad@uphs.upenn.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Creutzfeldt-Jakob Syndrome / complications*, pathology*, radionuclide imaging* Female Humans Magnetic Resonance Imaging / methods* Positron-Emission Tomography / methods* Vision Disorders / etiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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