| MRI markers of small vessel disease in lobar and deep hemispheric intracerebral hemorrhage. | |
| | |
MedLine Citation:
|
PMID: 20689084 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND PURPOSE: MRI evidence of small vessel disease is common in intracerebral hemorrhage (ICH). We hypothesized that ICH caused by cerebral amyloid angiopathy (CAA) or hypertensive vasculopathy would have different distributions of MRI T2 white matter hyperintensity (WMH) and microbleeds. METHODS: Data were analyzed from 133 consecutive patients with primary supratentorial ICH and adequate MRI sequences. CAA was diagnosed using the Boston criteria. WMH segmentation was performed using a validated semiautomated method. WMH and microbleeds were compared according to site of symptomatic hematoma origin (lobar versus deep) or by pattern of hemorrhages, including both hematomas and microbleeds, on MRI gradient recalled echo sequence (grouped as lobar only-probable CAA, lobar only-possible CAA, deep hemispheric only, or mixed lobar and deep hemorrhages). RESULTS: Patients with lobar and deep hemispheric hematoma had similar median normalized WMH volumes (19.5 cm versus 19.9 cm(3), P=0.74) and prevalence of >or=1 microbleed (54% versus 52%, P=0.99). The supratentorial WMH distribution was similar according to hemorrhage location category; however, the prevalence of brain stem T2 hyperintensity was lower in lobar hematoma versus deep hematoma (54% versus 70%, P=0.004). Mixed ICH was common (23%). Patients with mixed ICH had large normalized WMH volumes and a posterior distribution of cortical hemorrhages similar to that seen in CAA. CONCLUSIONS: WMH distribution is largely similar between CAA-related and non-CAA-related ICH. Mixed lobar and deep hemorrhages are seen on MRI gradient recalled echo sequence in up to one fourth of patients; in these patients, both hypertension and CAA may be contributing to the burden of WMH. |
| | |
Authors:
|
Eric E Smith; Kaveer R N Nandigam; Yu-Wei Chen; Jed Jeng; David Salat; Amy Halpin; Matthew Frosch; Lauren Wendell; Louis Fazen; Jonathan Rosand; Anand Viswanathan; Steven M Greenberg |
Related Documents
:
|
17990404 - Radiologic case study. extensive hematoma of the vastus intermedius showing components ... 2300864 - Rational approach to evaluation and management of spontaneous perirenal hemorrhage. 7413034 - Chronic epidural hematomas. 1951304 - Small bowel hematoma in a hemophiliac as a cause of pseudoappendicitis: diagnosis by ct... 21571694 - Early folding patterns and asymmetries of the normal human brain detected from in utero... 10452724 - The value of t2(*)-weighted mr images for the diagnosis of acoustic neuromas. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-08-05 |
Journal Detail:
|
Title: Stroke; a journal of cerebral circulation Volume: 41 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-08-31 Completed Date: 2010-09-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
|
Languages: eng Pagination: 1933-8 Citation Subset: IM |
Affiliation:
|
Department of Clinical Neurosciences, Calgary Stroke Program, University of Calgary, Calgary, Alberta, Canada. eesmith@ucalgary.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Brain / pathology*, physiopathology Brain Mapping Cerebral Amyloid Angiopathy / pathology*, physiopathology Cerebrovascular Disorders / etiology, pathology*, physiopathology Diagnosis, Differential Female Humans Hypertension / complications, pathology, physiopathology Image Processing, Computer-Assisted Magnetic Resonance Imaging* Male Middle Aged |
| Grant Support | |
ID/Acronym/Agency:
|
K23NS046327/NS/NINDS NIH HHS; K24NS056207/NS/NINDS NIH HHS; R01AG026484/AG/NIA NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ischemic Stroke Subtypes in a Japanese Population. Takashima Stroke Registry, 1988-2004.
Next Document: Diagnostic Threshold Values of Cerebral Perfusion Measured With Computed Tomography for Delayed Cere...