| MRI detection of VEGFR2 in vivo using a low molecular weight peptoid-(Gd)8-dendron for targeting. | |
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MedLine Citation:
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PMID: 20795620 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The synthesis of a polylysine dendron containing eight GdDOTA units conjugated to a peptoid dimer known to have a high affinity for the vascular endothelial growth factor receptor 2 (VEGFR2) is described. This simple low molecular weight system with a molecular r(1) relaxivity of ∼48 mM(-1) s(-1) is shown to enhance MR images of tumors grown in mice in vivo. |
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Authors:
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Luis M De León-Rodríguez; Angelo Lubag; D Gomika Udugamasooriya; Bettina Proneth; Rolf A Brekken; Xiankai Sun; Thomas Kodadek; A Dean Sherry |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of the American Chemical Society Volume: 132 ISSN: 1520-5126 ISO Abbreviation: J. Am. Chem. Soc. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-15 Completed Date: 2011-01-04 Revised Date: 2012-04-26 |
Medline Journal Info:
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Nlm Unique ID: 7503056 Medline TA: J Am Chem Soc Country: United States |
Other Details:
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Languages: eng Pagination: 12829-31 Citation Subset: IM |
Affiliation:
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Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9185, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anthracenes / chemistry* Cell Line, Tumor Gadolinium / chemistry* Humans Magnetic Resonance Imaging* Mice Mice, Nude Molecular Weight Peptoids / chemistry*, metabolism* Vascular Endothelial Growth Factor Receptor-2 / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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CA115531/CA/NCI NIH HHS; CA126608/CA/NCI NIH HHS; P41 RR002584-170034/RR/NCRR NIH HHS; P41 RR002584-22/RR/NCRR NIH HHS; P41 RR002584-23/RR/NCRR NIH HHS; R01 CA115531-05/CA/NCI NIH HHS; R01 CA115531-07/CA/NCI NIH HHS; RR02584/RR/NCRR NIH HHS; U24 CA126608-04/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anthracenes; 0/Peptoids; 0/dendron; 7440-54-2/Gadolinium; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-2 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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