Document Detail


MRI assessment of lean and adipose tissue distribution in female patients with Cushing's disease.
MedLine Citation:
PMID:  20550536     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Chronic hypercortisolemia due to Cushing's disease (CD) results in abnormal adipose tissue (AT) distribution. Whole-body magnetic resonance imaging (MRI) was used to examine lean and AT distribution in female patients with CD to further understand the role of glucocorticoid excess in the development of abnormal AT distribution and obesity.
DESIGN: Cross-sectional and case-control study.
PATIENTS: Fifteen women with CD and 12 healthy controls.
MEASUREMENTS: Mass of skeletal muscle (SM) and AT in the visceral (VAT), subcutaneous (SAT), and intermuscular (IMAT) compartments from whole-body MRI and serum levels of insulin, glucose, and leptin were measured.
RESULTS: CD patients had leptin values that correlated to total AT (TAT) and SAT (P < 0.05) but not to VAT. CD patients had higher VAT/TAT ratios (P < 0.01) and lower SAT/TAT ratios (P < 0.05) compared to controls. TAT, VAT, and trunk SAT (TrSAT) were greater in CD patients (P < 0.01). SM was less in CD (P < 0.001) but IMAT was not different.
CONCLUSIONS: TAT, VAT, trSAT, and the proportion of AT in the visceral depot were greater in CD although the proportion in the subcutaneous depot was less. SM was less but IMAT was not different. These findings have implications for understanding the role of cortisol in the abnormal AT distribution and metabolic risk seen in patients exposed to chronic excess glucocorticoids.
Authors:
Eliza B Geer; Wei Shen; Dympna Gallagher; Mark Punyanitya; Helen C Looker; Kalmon D Post; Pamela U Freda
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Clinical endocrinology     Volume:  73     ISSN:  1365-2265     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2011-01-19     Completed Date:  2011-05-11     Revised Date:  2012-10-09    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  469-75     Citation Subset:  IM    
Copyright Information:
© 2010 Blackwell Publishing Ltd.
Affiliation:
Department of Medicine, Mount Sinai Medical Center, St Luke’s-Roosevelt Hospital, Columbia University, New York, NY 10029, USA.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism*
Adult
Aged
Body Composition*
Case-Control Studies
Cross-Sectional Studies
Female
Humans
Hydrocortisone / blood
Insulin Resistance
Leptin / blood
Magnetic Resonance Imaging / methods*
Middle Aged
Pituitary ACTH Hypersecretion / metabolism*
Prospective Studies
Grant Support
ID/Acronym/Agency:
K23 DK 082617/DK/NIDDK NIH HHS; K23 DK082617/DK/NIDDK NIH HHS; K23 DK082617-01/DK/NIDDK NIH HHS; K23 DK082617-04/DK/NIDDK NIH HHS; K24 DK 073040/DK/NIDDK NIH HHS; K24 DK073040/DK/NIDDK NIH HHS; M01 RR000071/RR/NCRR NIH HHS; M01 RR000071-430600/RR/NCRR NIH HHS; MO1-RR-00071/RR/NCRR NIH HHS; P30-DK26687/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Leptin; 50-23-7/Hydrocortisone
Comments/Corrections

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