| MRA of the intracranial circulation in asymptomatic patients with sickle cell disease. | |
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MedLine Citation:
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PMID: 9569258 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: MR angiography (MRA) provides a mechanism for non-invasively studying blood flow, thus providing a new opportunity to study the intracranial circulation in asymptomatic sickle cell disease (SCD) patients. Although conventional angiography is the gold standard for the depiction of vascular anatomy, this is too invasive for an asymptomatic population. OBJECTIVE: To establish the range of appearances in asymptomatic SCD patients and to correlate brain MRI results (either sub-clinical abnormalities or normal brain parenchyma) with the MRA findings. MATERIALS AND METHODS: Brain MRI and MRA of the intracranial circulation was performed on 22 patients (13 male and 9 female, median age 7.5 years, range 1.3-20 years). Fourteen were homozygous SS and eight were SC. The median haematocrit at the time of MRI was 25.9 (range 13.8-33.3). RESULTS: On MR imaging, four patients had infarcts in eight vascular territories (six anterior and two posterior). In 3/4 of anterior vascular territories with infarction, long ( >/= 6 mm) segments of abnormal signal were seen at the internal carotid artery bifurcation with associated reduced distal flow. Short focal areas of abnormal signal were commonly seen where vessels branched, bifurcated or curved and were not associated with infarcts. These areas probably represent turbulence-related dephasing secondary to high velocity flow found in SCD. CONCLUSION: Long segments ( >/= 6 mm) of abnormal signal with reduced distal flow correlated with sub-clinical infarction. |
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Authors:
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A R Gillams; L McMahon; G Weinberg; A P Carter |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric radiology Volume: 28 ISSN: 0301-0449 ISO Abbreviation: Pediatr Radiol Publication Date: 1998 May |
Date Detail:
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Created Date: 1998-11-06 Completed Date: 1998-11-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0365332 Medline TA: Pediatr Radiol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 283-7 Citation Subset: IM |
Affiliation:
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The Department of Radiology, Boston City Hospital Imaging Foundation, Boston, Massachusetts, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anemia, Sickle Cell / pathology*, physiopathology Brain / pathology* Carotid Arteries / pathology Cerebral Arteries / pathology Cerebral Infarction / pathology Cerebrovascular Circulation / physiology* Child Child, Preschool Female Humans Infant Magnetic Resonance Angiography Magnetic Resonance Imaging Male Prospective Studies |
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