Document Detail

MR volumetric changes after diagnostic CSF removal in normal pressure hydrocephalus.
MedLine Citation:
PMID:  22592285     Owner:  NLM     Status:  Publisher    
Although diagnostic CSF removal in patients with suspected normal pressure hydrocephalus (NPH) is performed frequently, its impact on changes of the global brain volume and volume of the ventricles has not been studied in detail. We examined 20 patients with clinical and radiological signs of NPH. These received MRI prior to and immediately after diagnostic CSF removal, either via lumbar puncture (TAP, n = 10) or via external lumbar drainage (ELD, n = 10). Changes in global brain volume were assessed using SIENA, a tool from the FSL software library. Additionally, we determined the change of the lateral ventricles' volume by manual segmentation. Furthermore, we recorded systematic clinical assessments of the key features of NPH. The median volume of CSF removed was 35 ml in TAP patients and 406 ml in ELD patients. Changes in global brain volume were found in both patient groups. Brain volume change was significantly larger in ELD patients than in TAP patients (p = 0.022), and correlated with the volume of CSF removal (r = 0.628, p = 0.004). Brain volume expansion was most pronounced adjacent to the lateral ventricles, but also detectable in the temporal and frontal regions. The median ventricular volume decreased after CSF removal. Ventricular volume reduction was more pronounced in ELD patients than in TAP patients. This study quantifies for the first time immediate volumetric changes of global brain tissue and of ventricles after diagnostic CSF removal in NPH patients. In particular, we report evidence that CSF removal results in a change of the brain volume rather than only a change of the brain's shape.
Oliver C Singer; Julia Melber; Elke Hattingen; Alina Jurcoane; Fee Keil; Tobias Neumann-Haefelin; Johannes C Klein
Related Documents :
22404435 - Retrospective evaluation of bleeding tendency and simultaneous thrombin and plasmin gen...
22836855 - Patients with chronic pancreatitis are at increased risk for osteoporosis.
20516025 - Lipoprotein subclasses determined by nuclear magnetic resonance spectroscopy and corona...
22767485 - Association of periodontitis with increased colonization by prevotella nigrescens.
2897005 - Relative efficacy of various physical manoeuvres in the termination of junctional tachy...
23699595 - Abnormal pulmonary function test (pft) patterns in patients with chronic diffuse fibrot...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-17
Journal Detail:
Title:  Journal of neurology     Volume:  -     ISSN:  1432-1459     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Neurology, Goethe-University Frankfurt, Schleusenweg 2-16, 60528, Frankfurt/Main, Germany,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A Framework to Prevent and Control Tobacco among Adolescents and Children: Introducing the IMPACT Mo...
Next Document:  Tremor-spectrum in spinocerebellar ataxia type 3.