| MR renography using a dynamic gradient-echo sequence and low-dose gadopentetate dimeglumine as an alternative to radionuclide renography. | |
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MedLine Citation:
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PMID: 12876024 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Our aim was to evaluate the feasibility of acquiring an MR signal intensity-time renographic curve and dynamic serial images in a way similar to that of acquiring radionuclide renograms, with a dynamic gradient-echo sequence and a low-dose gadopentetate dimeglumine technique, using a commonly available 1.5-T MR scanner. SUBJECTS AND METHODS. Patients who underwent both radionuclide and MR renographic studies within a 3-month period were included in the analysis. This yielded 21 studies from 19 patients. Nineteen of the 21 studies were available for analysis. Two studies were excluded because of technical errors during MR renographic acquisition. Serial MR renograms were obtained using a dynamic two-dimensional spoiled gradient-echo fast low-angle shot T1-weighted sequence. Low-dose IV furosemide and gadopentetate dimeglumine (0.025 mmol/kg of body weight) were administered. Intensity-time curves were obtained from the manually selected regions of interest over the renal parenchyma and whole kidney for calculation of split renal function and assessment of urinary excretion, respectively. Results were compared with those obtained with radionuclide renography. RESULTS: Good correlation (Pearson's correlation coefficient, r = 0.97, p < 0.001) was observed when the volume-corrected split renal function acquired with MR renography was compared with that obtained with radionuclide renography. There was also good agreement in the excretory curve patterns (weighted kappa(observer 1) = 0.77 and kappa(observer 2) = 0.81) between the two techniques. CONCLUSION: Dynamic MR gradient-echo imaging with a low-dose gadopentetate dimeglumine technique can produce an intensity-time curve and serial dynamic images of the urinary system, in a way similar to that of radionuclide renography. This technique allows assessment of split renal function and urinary excretory status and is a feasible alternative to radionuclide renography. |
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Authors:
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Hui Seong Teh; Ee Sin Ang; Weng Cheong Wong; Say Beng Tan; Andrew Gee Seng Tan; Soke Miang Chng; Michael Beng Kiang Lin; Jeffery Seow Kuang Goh |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: AJR. American journal of roentgenology Volume: 181 ISSN: 0361-803X ISO Abbreviation: AJR Am J Roentgenol Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-07-23 Completed Date: 2003-08-28 Revised Date: 2008-02-15 |
Medline Journal Info:
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Nlm Unique ID: 7708173 Medline TA: AJR Am J Roentgenol Country: United States |
Other Details:
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Languages: eng Pagination: 441-50 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology, Changi General Hospital, 2, Simei St. 3, S, 529889 Singapore. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Contrast Media Diuretics / administration & dosage Female Furosemide / administration & dosage Gadolinium DTPA / diagnostic use Humans Kidney / physiopathology* Magnetic Resonance Imaging / methods* Male Middle Aged Radioisotope Renography* Radiopharmaceuticals / diagnostic use Technetium Tc 99m Mertiatide / diagnostic use Urologic Diseases / diagnosis |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Diuretics; 0/Radiopharmaceuticals; 125224-05-7/Technetium Tc 99m Mertiatide; 54-31-9/Furosemide; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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