Document Detail

MR-pathologic comparison of the upper spinal cord in different motor neuron diseases.
MedLine Citation:
PMID:  15785072     Owner:  NLM     Status:  MEDLINE    
This MRI study was performed to evaluate in vivo alterations of the spinal cord in defined subgroups of motor neuron diseases. Standard MRI examinations of the cervical and thoracic spinal cord in sporadic amyotrophic lateral sclerosis (ALS; n = 39), sporadic lower motor neuron disease (LMND; n = 19), Kennedy's disease (KD; n = 19) and a control group (n = 96) were analyzed with respect to spinal cord signal changes and the thickness of the spinal cord. No significant changes in thickness or signal alterations were observed when comparing ALS, LMND and control groups with one another. However, in KD patients significant upper spinal cord atrophy was detected at the cervical level as compared with all other groups. At the thoracic level, KD patients had significant upper cord atrophy as compared with controls and LMND. Marked atrophy of the upper spinal cord seems to be a feature of the KD-associated central-peripheral distal axonopathy.
Anne-Dorte Sperfeld; Volker Bretschneider; Leonie Flaith; Alexander Unrath; C Oliver Hanemann; Albert C Ludolph; Jan Kassubek
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2005-03-22
Journal Detail:
Title:  European neurology     Volume:  53     ISSN:  0014-3022     ISO Abbreviation:  Eur. Neurol.     Publication Date:  2005  
Date Detail:
Created Date:  2005-05-25     Completed Date:  2005-06-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0150760     Medline TA:  Eur Neurol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  74-7     Citation Subset:  IM    
Copyright Information:
Copyright 2005 S. Karger AG, Basel.
Department of Neurology, University of Ulm, Ulm, Germany.
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MeSH Terms
Age of Onset
Amyotrophic Lateral Sclerosis / pathology,  radiography
Cervical Vertebrae / pathology,  radiography
Magnetic Resonance Imaging
Middle Aged
Motor Neuron Disease / metabolism,  pathology*
Muscular Atrophy, Spinal / pathology,  radiography
Spinal Cord / pathology*,  radiography
Thoracic Vertebrae / pathology,  radiography

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