Document Detail

MR marrow signs of iron overload in transfusion-dependent patients with sickle cell disease.
MedLine Citation:
PMID:  8570314     Owner:  NLM     Status:  MEDLINE    
Magnetic resonance (MR) marrow signal in the axial and appendicular skeleton of 13 transfusion-dependent and chelated pediatric patients with sickle cell anemia (SSD) was compared with marrow signal in six non-transfusion-dependent patients with SSD. Hepatic, pancreatic, and renal MR signal were also evaluated. Indication for hypertransfusion therapy was primarily prior history of stroke. Transfusion-dependent patients had evidence of iron deposition throughout the imaged marrow and the liver, despite deferoxamine chelation therapy. Non-transfusion-dependent patients did not demonstrate grossly apparent signs of iron overload. Red marrow restoration was present in the spine, pelvis, and long bones and, in some patients, within the epiphyses. Marrow edema secondary to vaso-occlusive crises was evident in the metaphyses and diaphyses of long bones in areas of both red and fatty marrow and was best seen using fat-saturated T2-weighted imaging techniques.
T L Levin; S S Sheth; A Hurlet; S C Comerci; C Ruzal-Shapiro; S Piomelli; W E Berdon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric radiology     Volume:  25     ISSN:  0301-0449     ISO Abbreviation:  Pediatr Radiol     Publication Date:  1995  
Date Detail:
Created Date:  1996-03-01     Completed Date:  1996-03-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0365332     Medline TA:  Pediatr Radiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  614-9     Citation Subset:  IM    
Department of Pediatric Radiology, Babies & Children's Hospital, Columbia-Presbyterian Medical Center, 3959 Broadway, New York, NY 10032, USA.
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MeSH Terms
Anemia, Sickle Cell / metabolism,  pathology,  therapy*
Blood Transfusion* / adverse effects
Bone Marrow / metabolism,  pathology*
Hemosiderosis / diagnosis*
Iron / metabolism
Magnetic Resonance Imaging*
Reg. No./Substance:

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