| MR imaging of rectal cancer before and after chemoradiation therapy. | |
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MedLine Citation:
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PMID: 22434494 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: This study was done to determine the diagnostic accuracy of magnetic resonance (MR) imaging in patients with rectal carcinoma by comparing post-chemoradiation MR imaging with pathological specimens. MATERIALS AND METHODS: We enrolled 39 patients with locally advanced rectal cancer. All patients received chemoradiation therapy before surgery and neoadjuvant chemoradiation therapy followed by MR imaging. MR images were analysed by a team of two expert radiologists unaware of the clinical and histopathological findings. RESULTS: Following neoadjuvant chemoradiation therapy, the analysis of MR images showed 23 (59%) patients with a rectal disease staged ≤T2 and 16 (41%) with a disease staged >T2. Post-treatment histological staging (TNM) revealed 13 patients with a disease >T2 and 26 patients with a disease ≤T2. Cohen's kappa to measure concordance between post-chemoradiation MR staging and histological response showed 83.6% concordance for disease confined to the serosa (≤T3): concordance was 97.22% for disease ≤N1 and 33.33% for disease >N1. CONCLUSIONS: MR imaging is critical for discovering T3 disease; moreover, morphological MR imaging does not always provide the opportunity to discern small residual cancer cells hidden in fibrotic tissue that could cause involvement of circumferential resection margin (CRM) on histology. |
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Authors:
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R Del Vescovo; L E Trodella; I Sansoni; R L Cazzato; S Battisti; F Giurazza; S Ramella; F Cellini; R F Grasso; L Trodella; B Beomonte Zobel |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-20 |
Journal Detail:
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Title: La Radiologia medica Volume: - ISSN: 1826-6983 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0177625 Medline TA: Radiol Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Campus Bio-Medico University of Rome, Via Alvaro del Portillo 200, Trigoria, Rome, Italy, r.delvescovo@unicampus.it. |
Vernacular Title:
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La risonanza magnetica nella valutazione dell'adenocarcinoma del retto prima e dopo trattamento chemio-radioterapico. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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