Document Detail


MR imaging of myocardial perfusion and viability.
MedLine Citation:
PMID:  12797510     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CMR is a rapidly developing new modality with applications in clinical cardiology for detection and assessment of myocardial ischemia and viability. CMR perfusion results for the detection of ischemia in comparison with stress echocardiography and scintigraphic techniques are reasonable, but all the studies reported to date have been conduced in selected patients. Larger studies in patient populations reflecting a broader spectrum of disease are necessary before perfusion CMR can be envisaged as a clinically reliable and robust diagnostic tool. Other CMR techniques provide a variety of novel methods of obtaining information on postischemic viability. Signs of viability that can be observed by CMR are the absence of late gadolinium-based contrast enhancement in a myocardial region involved in a recent infarct, any sign of wall thickening at rest (which is detectable with high accuracy by CMR), wall thickening after stimulation by low-dose dobutamine, and preserved wall thickness. Conversely, myocardial necrosis is characterized by signal enhancement of the infarct area after injection of Gd-DTPA, reduced wall thickness in chronic infarcts, and absence of a contractile reserve during dobutamine stimulation. Dobutamine CMR and late enhancement contrast-enhanced CMR predict contractile improvement after revascularization.
Authors:
Anja Wagner; Heiko Mahrholdt; Udo Sechtem; Raymond J Kim; Robert M Judd
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Magnetic resonance imaging clinics of North America     Volume:  11     ISSN:  1064-9689     ISO Abbreviation:  Magn Reson Imaging Clin N Am     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-06-11     Completed Date:  2003-07-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9422762     Medline TA:  Magn Reson Imaging Clin N Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  49-66     Citation Subset:  IM    
Affiliation:
Duke Cardiovascular Magnetic Resonance Center, Duke University Medical Center, Box 3934, Durham, NC, USA. anja.wagner@dcmrc.mc.duke.edu
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MeSH Terms
Descriptor/Qualifier:
Contrast Media
Humans
Magnetic Resonance Imaging / methods*
Myocardial Contraction
Myocardial Ischemia / diagnosis*,  physiopathology
Myocardium / pathology*
Grant Support
ID/Acronym/Agency:
R01-HL63268/HL/NHLBI NIH HHS; R01-HL64726/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Contrast Media

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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