| MR imaging detection of cerebral microbleeds: effect of susceptibility-weighted imaging, section thickness, and field strength. | |
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MedLine Citation:
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PMID: 19001544 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: The emergence of cerebral microbleeds (CMB) as common MR imaging findings raises the question of how MR imaging parameters influence CMB detection. To evaluate the effects of modified gradient recalled-echo (GRE) MR imaging methods, we performed an analysis of sequence, section thickness, and field strength on CMB imaging properties and detection in subjects with cerebral amyloid angiopathy (CAA), a condition associated with microhemorrhage. MATERIALS AND METHODS: Multiple MR images were obtained from subjects with probable CAA, with varying sequences (GRE versus susceptibility-weighted imaging [SWI]), section thicknesses (1.2-1.5 versus 5 mm), and magnetic field strengths (1.5T versus 3T). Individual CMB were manually identified and analyzed for contrast index (lesion intensity normalized to normal-appearing white matter signal intensity) and diameter. CMB counts were compared between 1.5T thick-section GRE and thin-section SWI for 3 subjects who underwent both protocols in the same scanning session. RESULTS: With other parameters constant, use of SWI, thinner sections, and a higher field strength yielded medium-to-large gains in CMB contrast index (CI; Cohen d 0.71-1.87). SWI was also associated with small increases in CMB diameter (Cohen d <0.3). Conventional thick-section GRE identified only 33% of CMB (103 of 310) seen on thin-section SWI. Lesions prospectively identified on GRE had significantly greater CI and diameter measured on the GRE image than those not prospectively identified. CONCLUSIONS: The examined alternatives to conventional GRE MR imaging yield substantially improved CMB contrast and sensitivity for detection. Future studies based on these techniques will most likely yield even higher prevalence estimates for CMB. |
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Authors:
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R N K Nandigam; A Viswanathan; P Delgado; M E Skehan; E E Smith; J Rosand; S M Greenberg; B C Dickerson |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural Date: 2008-11-11 |
Journal Detail:
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Title: AJNR. American journal of neuroradiology Volume: 30 ISSN: 1936-959X ISO Abbreviation: AJNR Am J Neuroradiol Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-02-11 Completed Date: 2009-04-23 Revised Date: 2011-05-05 |
Medline Journal Info:
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Nlm Unique ID: 8003708 Medline TA: AJNR Am J Neuroradiol Country: United States |
Other Details:
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Languages: eng Pagination: 338-43 Citation Subset: IM |
Affiliation:
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Hemorrhagic Stroke Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Cerebral Amyloid Angiopathy / epidemiology, pathology* Cerebral Hemorrhage / epidemiology, pathology* Humans Longitudinal Studies Magnetic Resonance Imaging / methods* Microvessels / pathology* Middle Aged Prevalence Prospective Studies |
| Grant Support | |
ID/Acronym/Agency:
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K24 NS056207/NS/NINDS NIH HHS; R01 AG026484/AG/NIA NIH HHS; R01 AG029411/AG/NIA NIH HHS; R01 AG029411-02/AG/NIA NIH HHS |
| Comments/Corrections | |
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