Document Detail

MR imaging of acute myocardial infarction: value of Gd-DTPA.
MedLine Citation:
PMID:  3257603     Owner:  NLM     Status:  MEDLINE    
The potential of gadolinium (Gd)-DTPA to improve the detection of acute myocardial infarction by MR has been shown in experimental canine studies. To determine its value in humans, we studied five patients 2-17 days after myocardial infarction by using ECG-gated MR before and after administration of 0.1 mmol/kg Gd-DTPA. One patient had a rupture of the interventricular septum, complicating an acute inferior-wall infarction. Spin-echo images were obtained before and immediately after injection of Gd-DTPA and were repeated every 10 min for up to 40 min. In four patients, intensity-vs-time curves revealed increasing signal intensity in the infarcted area in the first 20 min after injection of gadolinium. Contrast between normal and infarcted myocardium was greatest 20-30 min after Gd-DTPA injection. In one patient, increasing signal intensity of the infarcted myocardium was observed up to 40 min after Gd-DTPA injection. The precontrast intensity ratio between infarcted and normal myocardium was 1.1 at echo time (TE) = 30 msec and was 1.4 at TE = 60 msec (p less than .05). The postcontrast intensity ratio was 1.6, which was not statistically different from the ratio at TE = 60 msec but which was significantly higher than the ratio at TE = 30 msec (p less than .01). Infarct definition was substantially improved on postcontrast images. The septal rupture was clearly seen, and the infarcted myocardium surrounding the septal rupture showed enhancement on postcontrast images. These results suggest that Gd-DTPA can improve MR visualization and detection of acute myocardial infarction.
A de Roos; J Doornbos; E E van der Wall; A E van Voorthuisen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  AJR. American journal of roentgenology     Volume:  150     ISSN:  0361-803X     ISO Abbreviation:  AJR Am J Roentgenol     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-03-23     Completed Date:  1988-03-23     Revised Date:  2008-02-15    
Medline Journal Info:
Nlm Unique ID:  7708173     Medline TA:  AJR Am J Roentgenol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  531-4     Citation Subset:  AIM; IM    
Department of Diagnostic Radiology, University Hospital Leiden, the Netherlands.
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MeSH Terms
Gadolinium / diagnostic use*
Gadolinium DTPA
Magnetic Resonance Imaging*
Middle Aged
Myocardial Infarction / pathology*,  physiopathology
Myocardium / pathology
Organometallic Compounds / diagnostic use*
Pentetic Acid / diagnostic use*
Reg. No./Substance:
0/Organometallic Compounds; 67-43-6/Pentetic Acid; 7440-54-2/Gadolinium; 80529-93-7/Gadolinium DTPA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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