| MR imaging of acute experimental ischemia in cats. | |
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MedLine Citation:
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PMID: 3082146 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The evolution of acute cerebral ischemia was documented by magnetic resonance (MR) imaging in 13 mongrel cats with occlusion of the middle cerebral artery through a transorbital approach. The animals were imaged under anesthesia at intervals from 30 min to 10 days after production of the lesion. An MR imager operating at 0.35 T was used with multislice, multi-spin-echo technique (TR = 500-2000 msec; TE = 28, 56 msec). The animals were sacrificed after imaging for pathologic correlation. Infarcts beyond 4 hr of age were visualized in all subjects. The earliest infarct was seen at 30 min (two cats) as an area of high signal intensity on T2-weighted images. In three other cats, however, 3-hr-old infarcts were not detectable. In one animal, a hemorrhage within a 1-week-old area of infarction was not characterized by MR imaging but was identified on CT scanning. The mass effect of the infarction appeared greatest at 2-4 days after infarction. The basal ganglia showed ischemic effects to best advantage. MR imaging offers previously unavailable sensitivity for the early noninvasive detection of cerebral ischemia in vivo. |
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Authors:
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M Brant-Zawadzki; B Pereira; P Weinstein; S Moore; W Kucharczyk; I Berry; M McNamara; N Derugin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: AJNR. American journal of neuroradiology Volume: 7 ISSN: 0195-6108 ISO Abbreviation: AJNR Am J Neuroradiol Publication Date: 1986 Jan-Feb |
Date Detail:
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Created Date: 1986-04-02 Completed Date: 1986-04-02 Revised Date: 2008-02-14 |
Medline Journal Info:
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Nlm Unique ID: 8003708 Medline TA: AJNR Am J Neuroradiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 7-11 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / pathology Cats Cerebral Hemorrhage / pathology Cerebral Infarction / pathology Evaluation Studies as Topic Ischemic Attack, Transient / diagnosis*, pathology Magnetic Resonance Spectroscopy / diagnostic use* Time Factors |
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