| MR-guided laser irradiation of recurrent glioblastomas. | |
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MedLine Citation:
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PMID: 16270287 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We treated two patients with recurrent glioblastoma multiforme using Nd:YAG laser irradiation in the framework of a salvage therapy. The underlying concept is to achieve cytoreduction by partial coagulation of the tumor. Magnetic resonance imaging (MRI) follow-up examinations revealed a volume reduction of the laser-irradiated areas, while the untreated parts of the tumor exhibited a progression. The survival time after the diagnosis of the recurrence was 16 and 20 months, respectively, which is substantially (about four times) longer than the natural history of the disease would suggest. In conclusion, cytoreduction by laser irradiation may be a promising option for patients suffering from recurrent glioblastoma multiforme. Future work should optimize the therapeutic regimen and evaluate this treatment approach in controlled clinical trials. |
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Authors:
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Hans-Joachim Schwarzmaier; Frank Eickmeyer; Wernholt von Tempelhoff; Volkhard Ulrich Fiedler; Hendrik Niehoff; Slif Dagobert Ulrich; Frank Ulrich |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 22 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-11-28 Completed Date: 2006-02-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 799-803 Citation Subset: IM |
Affiliation:
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Department of Medical Technology, Klinikum Krefeld, University of Düsseldorf Medical School, Krefeld, Germany. schwarzmaier@klinikum-krefeld.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Brain Neoplasms / mortality, surgery* Glioblastoma / mortality, surgery* Humans Laser Coagulation* / methods Magnetic Resonance Imaging* Male Middle Aged Neoplasm Recurrence, Local Survival Rate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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