Document Detail

MR findings of cartilage invasion by laryngeal cancer: value in predicting outcome of radiation therapy.
MedLine Citation:
PMID:  2305047     Owner:  NLM     Status:  MEDLINE    
Thirty-nine patients who underwent radiation therapy with curative intent for laryngeal cancer were examined before treatment with magnetic resonance (MR) imaging, between November 1985 and January 1987. MR findings of cartilage invasion were correlated with the effectiveness of radiation treatment. Adequate interpretation of the MR examinations was not possible in four cases (10%). Cartilage invasion was found in 16 of the 35 remaining patients and was found even in small glottic lesions, clinically staged as T1b and T2. Laryngeal cancer recurred in 10 of the 16 patients with cartilage invasion shown by MR imaging. The presence of even small foci of invasion of the thyroid cartilage by laryngeal cancer appeared to increase the subsequent risk of tumor recurrence. Cartilage invasion seen at MR imaging might therefore shift the preference to partial laryngectomy as the initial treatment for small glottic tumors. Alternatively, radiation therapy alone would appear to require stringent follow-up to detect possible recurrence.
J A Castelijns; R P Golding; C van Schaik; J Valk; G B Snow
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Radiology     Volume:  174     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-03-27     Completed Date:  1990-03-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  669-73     Citation Subset:  AIM; IM    
Department of Radiology, Free University Hospital, Amsterdam, The Netherlands.
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MeSH Terms
Aged, 80 and over
Carcinoma, Squamous Cell / diagnosis*,  radiotherapy
Laryngeal Cartilages / pathology*
Laryngeal Neoplasms / diagnosis*,  radiotherapy
Magnetic Resonance Imaging
Middle Aged
Neoplasm Invasiveness
Neoplasm Recurrence, Local
Radiotherapy Dosage

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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