Document Detail


MR features of developing periventricular white matter in preterm infants: evidence of glial cell migration.
MedLine Citation:
PMID:  9613523     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: MR imaging of the brain is increasingly used in the investigation of the newborn, but little information is available on the normal appearance of the developing brain. We scanned a series of newborn infants in an attempt to define the normal appearance of developing periventricular white matter and to assess how pathologic conditions may modify this appearance. METHODS: Sixty-eight newborn infants, median postmenstrual age (PMA) 34 weeks (range, 24 to 42 weeks), were subdivided into two groups: group A (n = 33), which included those with normal clinical and sonographic examinations, and group B (n = 35), which contained those with evidence of neuroabnormality detected prior to the MR study, either clinically or by cerebral sonography. Images were acquired in two planes on a 1.5-T imager using turbo spin-echo pulse sequences. RESULTS: Symmetric periventricular bands of reduced signal intensity were noted in the frontal periventricular white matter on T2-weighted images in 98% of group A infants and in 97% of group B infants. The number of bands was inversely related to PMA. The reduction in number of bands with increasing PMA was delayed in group B infants. CONCLUSION: The uniform appearance of periventricular bands in a population of healthy infants and their relationship to the infants' maturity is consistent with the results of previous histologic studies. These studies demonstrate the presence of migrating glial cells within the periventricular white matter of infants beyond 20 weeks' gestation, when neuronal migration to the cortex is complete. We postulate that the bands seen on T2-weighted images represent groups of migrating glial cells, providing a further marker of cerebral maturation.
Authors:
A M Childs; L A Ramenghi; D J Evans; J Ridgeway; M Saysell; D Martinez; R Arthur; S Tanner; M I Levene
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  19     ISSN:  0195-6108     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-07-27     Completed Date:  1998-07-27     Revised Date:  2008-02-14    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  971-6     Citation Subset:  IM    
Affiliation:
Centre for Reproduction, Growth and Development, University of Leeds, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Brain / anatomy & histology,  cytology,  pathology
Brain Diseases / diagnosis
Cell Movement / physiology
Cerebral Ventricles / anatomy & histology*,  cytology
Gestational Age
Humans
Infant, Newborn
Infant, Premature*
Leukomalacia, Periventricular / diagnosis
Magnetic Resonance Imaging
Male
Neuroglia / physiology*
Reference Values

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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