| MR diffusion tensor and perfusion-weighted imaging in preoperative grading of supratentorial nonenhancing gliomas. | |
| | |
MedLine Citation:
|
PMID: 21297125 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We evaluate the value of MR diffusion tensor imaging (DTI) and dynamic susceptibility-weighted contrast material-enhanced perfusion-weighted imaging (PWI) in preoperative grading of supratentorial nonenhancing gliomas. This institutional review board-approved, Health Insurance Portability and Accountability Act-compliant retrospective study involved 52 patients: 37 with low-grade gliomas (LGGs) and 15 with high-grade gliomas (HGGs). The mean trace apparent diffusion coefficient (ADC), minimal ADC, mean fractional anisotropy (FA), maximal FA, and maximal relative cerebral blood volume (rCBV) ratio of the lesions were measured and compared between LGG and HGG. The efficacy of the above parameters in grading supratentorial nonenhancing gliomas was evaluated. There was no significant difference in rCBV ratio, minimal ADC, and mean ADC between LGG and HGG (p > 0.05). The mean and maximal FA values of LGG were significantly lower than the values of HGG (p < 0.001). The receiver operating characteristic analysis showed that the mean FA with a cutoff value of 0.129 and the maximal FA with a cutoff value of 0.219 could differentiate between LGG and HGG with specificity of 69.2% and 76.9%, respectively, and sensitivity of 93.3% and 100.0%, respectively. The combination of mean FA and maximal FA based on the linear discriminant analysis improved the diagnostic accuracy with specificity of 92.3% and sensitivity of 86.7%. These findings were better than maximal rCBV ratio, mean ADC, and minimum ADC. The mean FA and maximal FA, used individually or combined, may be useful in preoperative grading of supratentorial nonenhancing gliomas. |
| | |
Authors:
|
Xiang Liu; Wei Tian; Balasubramanya Kolar; Gabrielle A Yeaney; Xing Qiu; Mahlon D Johnson; Sven Ekholm |
Related Documents
:
|
18607205 - Presurgical functional mapping with functional mri. 17727825 - Exogenous testosterone enhances responsiveness to social threat in the neural circuitry... 15177085 - The hippocampus and depression. 21273755 - Posterior fossa epidermoid cysts presenting with unusual radiological appearances. 16206655 - Mri in multiple myeloma with orbital and dural invasion. 6728545 - Diagnosis of liver-spleen abscesses in children--with emphasis on ultrasound for the in... |
Publication Detail:
|
Type: Journal Article Date: 2011-02-04 |
Journal Detail:
|
Title: Neuro-oncology Volume: 13 ISSN: 1523-5866 ISO Abbreviation: Neuro-oncology Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-03-24 Completed Date: 2011-07-26 Revised Date: 2012-04-02 |
Medline Journal Info:
|
Nlm Unique ID: 100887420 Medline TA: Neuro Oncol Country: United States |
Other Details:
|
Languages: eng Pagination: 447-55 Citation Subset: IM |
Affiliation:
|
Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY 14642-8638, USA. Xiang_Liu@URMC.Rochester.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Brain Neoplasms / diagnosis*, surgery Contrast Media / diagnostic use* Diffusion Magnetic Resonance Imaging* Female Glioma / diagnosis*, surgery Humans Male Perfusion Imaging Preoperative Care Prognosis Retrospective Studies Sensitivity and Specificity Supratentorial Neoplasms / diagnosis*, surgery |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Catecholamine-dependent wide QRS complex tachycardia in a 71-year-old male 'super athlete'
Next Document: MRI as a central component of clinical trials analysis in brainstem glioma: a report from the Pediat...