| MR derived volumetric flow rate waveforms at locations within the common carotid, internal carotid, and basilar arteries. | |
| | |
MedLine Citation:
|
PMID: 19756018 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The volumetric flow rate (VFR) waveform over the cardiac cycle in the cerebral vasculature is a significant factor in many studies, which involve cerebrovascular function. Perhaps contrary to expectation, the literature in this area is sparse and the characteristics of blood flow waveforms are ill defined. A better understanding of the variation of blood flow rate and pulsatility may aid our knowledge of risk factors involved in diseases and conditions, such as stroke, arteriovenous malformation, or aneurysm rupture. This study sought to characterise the blood flow waveform over the cardiac cycle at levels within the carotid artery and basilar artery (BA) in a normal cohort. The study cohort consisted of 22 subjects (recruitment age: 20 to 40 years) with no history of vascular disease (median age=26 years, interquartile range=25 to 32 years). Two-dimensional quantitative phase-contrast magnetic resonance imaging was performed on each subject at nine anatomic locations within the carotid artery and BA. Significant differences in pulsatility were present within the carotid tree. Archetypal VFR waveforms were established for this group at the nine locations. A normal individual's VFR waveform at a location within the carotid tree can be estimated by taking the group's archetypal waveform for that location, and scaling by the individual's average flow rate. |
| | |
Authors:
|
Matthew N Gwilliam; Nigel Hoggard; David Capener; Pankaj Singh; Alberto Marzo; Prashant K Verma; Iain D Wilkinson |
Related Documents
:
|
8891578 - Investigations with gmc2021 in experimental models predictive of antimigraine activity ... 572038 - The effects of blood osmolality changes on cat carotid body chemoreceptors in vivo. 15300218 - Impact of il-1beta on flow-induced outward arterial remodeling. 3143178 - A comparison of po2, pco2, ph and bicarbonate in blood from the carotid and coccygeal a... 22388608 - Brain hemodynamics in patients with end-stage renal disease between hemodialysis sessions. 11287528 - A randomized, prospective evaluation of the tesio, ash split, and opti-flow hemodialysi... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-16 |
Journal Detail:
|
Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 29 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2009-11-30 Completed Date: 2010-01-26 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
|
Languages: eng Pagination: 1975-82 Citation Subset: IM |
Affiliation:
|
Medical Physics and Clinical Engineering, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Basilar Artery / physiology* Blood Flow Velocity* Carotid Arteries / physiology* Carotid Artery, Common / physiology Cohort Studies Female Humans Magnetic Resonance Imaging / methods* Male Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: No Article Title
Next Document: Improved measurement of drug exposure in the brain using drug-specific correction for residual blood...