Document Detail


An MR-compatible bicycle ergometer for in-magnet whole-body human exercise testing.
MedLine Citation:
PMID:  19918886     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An MR-compatible ergometer was developed for in-magnet whole-body human exercise testing. Designed on the basis of conventional mechanically braked bicycle ergometers and constructed from nonferrous materials, the ergometer was implemented on a 1.5-T whole-body MR scanner. A spectrometer interface was constructed using standard scanner hardware, complemented with custom-built parts and software to enable gated data acquisition during exercise. High-quality 31P NMR spectra were reproducibly obtained from the medial head of the quadriceps muscle of the right leg of eight healthy subjects during two-legged high-frequency pedaling (80 revolutions per minute) at three incremental workloads, including maximal. Muscle phosphocreatine content dropped 82%, from 32.2+/-1.0 mM at rest to 5.7+/-1.1 mM at maximal workload (mean+/-standard error; n=8), indicating that the majority of quadriceps motor units were recruited. The cardiovascular load of the exercise was likewise significant, as evidenced by heart rates of 150 (+/-10%) beats per minute, measured immediately afterward. As such, the newly developed MR bicycling exercise equipment offers a powerful new tool for clinical musculoskeletal and cardiovascular MR investigation. The basic design of the ergometer is highly generic and adaptable for application on a wide selection of whole-body MR scanners.
Authors:
Jeroen A L Jeneson; Joep P J Schmitz; Peter A J Hilbers; Klaas Nicolay
Related Documents :
15451556 - Methyl-paraoxon comparative inhibition kinetics for acetylcholinesterases from brain of...
2584276 - Seizure-induced damage to substantia nigra and globus pallidus is accompanied by pronou...
1510146 - Nmr visibility of pi in perfused rat hearts is affected by changes in substrate and con...
2226826 - Heterogeneity of metabolic response to muscular exercise in humans. new criteria of inv...
3678226 - Human muscle function following prolonged eccentric exercise.
18801926 - A panel study in congestive heart failure to estimate the short-term effects from perso...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  63     ISSN:  1522-2594     ISO Abbreviation:  Magn Reson Med     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-28     Completed Date:  2010-03-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  257-61     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 Wiley-Liss, Inc.
Affiliation:
Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands. j.a.l.jeneson@tue.nl
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Artifacts*
Equipment Design
Equipment Failure Analysis
Exercise Test / instrumentation*
Humans
Image Enhancement / instrumentation*
Magnetic Resonance Imaging / instrumentation*
Magnetics / instrumentation*
Reproducibility of Results
Sensitivity and Specificity
Whole Body Imaging / instrumentation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Improved secretion of molecular chaperone-assisted human IgG in silkworm, and no alterations in thei...
Next Document:  Stabilization of invertase by molecular engineering.