Document Detail

MR characterization of cardiac abnormalities in HIV+ individuals with increased BNP levels.
MedLine Citation:
PMID:  17513188     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To characterize cardiac abnormalities in HIV+ patients with increased serum B-type natiuretic peptide (BNP) by contrast-enhanced cardiac magnetic resonance imaging (MRI). DESIGN: Non-blinded prospective consecutive cohort evaluation. METHODS: More than 400 HIV+ patients were screened for potential BNP alterations. 16 met the inclusion criteria of elevated BNP levels and 12 patients could finally be enrolled. MRI analysis comprised function, oedema and late enhancement sequences. RESULTS: Patients exhibited a median serum BNP level of 249 pg/ml. Based on MRI, diagnosis of left ventricular hypertrophy (n = 3), myocarditis (n = 2), chronic myocardial infarction (n = 2), dilated cardiomyopathy (n=1) and right ventricular failure (n = 1) was made. CONCLUSIONS: Although no specific MR pattern was found, MR allowed characterization of the underlying cardiac pathologies in 82% of HIV+ patients with elevated BNP levels.
F Breuckmann; K Nassenstein; J Kondratieva; S Esser; R Erbel; A Potthoff; N H Brockmeyer; T Neumann; J Barkhausen; ;
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of medical research     Volume:  12     ISSN:  0949-2321     ISO Abbreviation:  Eur. J. Med. Res.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-21     Completed Date:  2007-07-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9517857     Medline TA:  Eur J Med Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  185-90     Citation Subset:  IM    
Department of Cardiology, West German Heart Center, Germany.
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MeSH Terms
HIV Infections / blood,  complications*
Heart Diseases / blood,  diagnosis*,  virology*
Magnetic Resonance Imaging
Natriuretic Peptide, Brain / blood*
Radiographic Image Enhancement
Reg. No./Substance:
114471-18-0/Natriuretic Peptide, Brain

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