Document Detail


MR-based visualization and quantification of three-dimensional flow characteristics in the portal venous system.
MedLine Citation:
PMID:  20677279     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To evaluate the feasibility of time-resolved flow-sensitive MRI for the three-dimensional (3D) visualization and quantification of normal and pathological portal venous (PV) hemodynamics.
MATERIALS AND METHODS: Portal venous hemodynamics were evaluated in 18 healthy volunteers and 5 patients with liver cirrhosis. ECG- and adaptive respiratory navigator gated flow-sensitive 4D MRI (time-resolved 3D MRI with three-directional velocity encoding) was performed on a 3 Tesla MR system (TRIO, Siemens, Germany). Qualitative flow analysis was achieved using 3D streamlines and time-resolved particle traces originating from seven emitter planes precisely placed at anatomical landmarks in the PV system. Quantitative analysis included retrospective extraction of regional peak and mean velocities and vessel area. Results were compared with standard 2D flow-sensitive MRI and to the reference standard Doppler ultrasound.
RESULTS: Qualitative flow analysis was successfully used in the entire PV system. Venous hemodynamics in all major branches in 17 of 18 volunteers and 3 of 5 patients were reliably depicted with good interobserver agreement (kappa = 0.62). Quantitative analysis revealed no significant differences and moderate agreement for peak velocities between 3D MR and 2D MRI (r = 0.46) and Doppler ultrasound (US) (r = 0.35) and for mean velocities between 3D and 2D MRI (r = 0.41). The PV area was significantly (P < 0.01) higher in 3D and 2D MRI compared with US.
CONCLUSION: We successfully applied 3D MR velocity mapping in the PV system, providing a detailed qualitative and quantitative analysis of normal and pathological hemodynamics.
Authors:
Zoran Stankovic; Alex Frydrychowicz; Zoltan Csatari; Elisabeth Panther; Peter Deibert; Wulf Euringer; Wolfgang Kreisel; Maximilian Russe; Simon Bauer; Mathias Langer; Michael Markl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  32     ISSN:  1522-2586     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-02     Completed Date:  2010-11-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  466-75     Citation Subset:  IM    
Copyright Information:
2010 Wiley-Liss, Inc.
Affiliation:
Department of Diagnostic Radiology and Medical Physics, University Hospital Freiburg, Freiburg, Germany. zoran.stankovic@uniklinik-freiburg.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Electrocardiography / methods
Female
Hemodynamics
Humans
Image Processing, Computer-Assisted / methods*
Imaging, Three-Dimensional / methods
Liver Cirrhosis / pathology*
Magnetic Resonance Imaging / methods*
Male
Middle Aged
Portal Vein / pathology*
Respiration
Ultrasonography, Doppler / methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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