| MR imaging to assess immediate response to irreversible electroporation for targeted ablation of liver tissues: preclinical feasibility studies in a rodent model. | |
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MedLine Citation:
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PMID: 20656834 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To test the hypothesis that magnetic resonance (MR) imaging measurements can be used to immediately detect treated tissue regions after irreversible electroporation (IRE) ablation procedures in rodent liver tissues. MATERIALS AND METHODS: All experiments received institutional animal care and use committee approval. In four rats for preliminary studies and 18 rats for formal assessment, MR imaging-compatible electrodes were inserted into the liver and MR imaging-monitored IRE procedures were performed at one of three electrode voltages (1000, 1500, or 2500 V), with T1- and T2-weighted images acquired before and immediately after application of the IRE pulses. MR imaging measurements were compared with both finite element modeling (FEM)-anticipated ablation zones and histologically confirmed ablation zones at necropsy. Intraclass and Spearman correlation coefficients were calculated for statistical comparisons. RESULTS: MR imaging measurements permitted immediate depiction of IRE ablation zones that were hypointense on T1-weighted images and hyperintense on T2-weighted images. MR imaging-based measurements demonstrated excellent consistency with FEM-anticipated ablation zones (r > 0.90 and P < .001 for both T1- and T2-weighted images). MR imaging measurements were also highly correlated with histologically confirmed ablation zone measurements (rho > 0.90 and P < .001 for both T1- and T2-weighted images). CONCLUSION: MR imaging permits immediate depiction of ablated tissue zones for monitoring of IRE ablation procedures. These measurements could potentially be used during treatment to elicit repeat application of IRE pulses or adjustments to electrode positions to ensure complete treatment of targeted lesions. |
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Authors:
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Yue Zhang; Yang Guo; Ann B Ragin; Robert J Lewandowski; Guang-Yu Yang; Grace M Nijm; Alan V Sahakian; Reed A Omary; Andrew C Larson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Radiology Volume: 256 ISSN: 1527-1315 ISO Abbreviation: Radiology Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-26 Completed Date: 2010-09-24 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 424-32 Citation Subset: AIM; IM |
Affiliation:
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Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Catheter Ablation / methods* Electroporation / methods* Feasibility Studies Hepatectomy / methods* Humans Liver / anatomy & histology*, surgery* Magnetic Resonance Imaging / methods* Male Models, Animal Rats Rats, Sprague-Dawley Surgery, Computer-Assisted / methods* |
| Grant Support | |
ID/Acronym/Agency:
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CA134719/CA/NCI NIH HHS; R01 CA134719-01/CA/NCI NIH HHS; UL1 RR025741/RR/NCRR NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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