Document Detail

MR image-based geometric and hemodynamic investigation of the right coronary artery with dynamic vessel motion.
MedLine Citation:
PMID:  20364324     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to develop a fully subject-specific model of the right coronary artery (RCA), including dynamic vessel motion, for computational analysis to assess the effects of cardiac-induced motion on hemodynamics and resulting wall shear stress (WSS). Vascular geometries were acquired in the right coronary artery (RCA) of a healthy volunteer using a navigator-gated interleaved spiral sequence at 14 time points during the cardiac cycle. A high temporal resolution velocity waveform was also acquired in the proximal region. Cardiac-induced dynamic vessel motion was calculated by interpolating the geometries with an active contour model and a computational fluid dynamic (CFD) simulation with fully subject-specific information was carried out using this model. The results showed the expected variation of vessel radius and curvature throughout the cardiac cycle, and also revealed that dynamic motion of the right coronary artery consequent to cardiac motion had significant effects on instantaneous WSS and oscillatory shear index. Subject-specific MRI-based CFD is feasible and, if scan duration could be shortened, this method may have potential as a non-invasive tool to investigate the physiological and pathological role of hemodynamics in human coronary arteries.
Ryo Torii; Jennifer Keegan; Nigel B Wood; Andrew W Dowsey; Alun D Hughes; Guang-Zhong Yang; David N Firmin; Simon A McG Thom; X Yun Xu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-03
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  38     ISSN:  1573-9686     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-09     Completed Date:  2010-12-07     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2606-20     Citation Subset:  IM    
Department of Chemical Engineering, Imperial College London, South Kensington Campus, London SW72AZ, UK.
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MeSH Terms
Aorta / physiology*
Blood Vessels / physiology
Coronary Vessels / physiology*
Heart / physiology
Hemodynamics / physiology
Magnetic Resonance Angiography / methods
Stress, Mechanical
Grant Support
PG/04/078//British Heart Foundation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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