Document Detail

MR and CT imaging of 24 pleomorphic xanthoastrocytomas (PXA) and a review of the literature.
MedLine Citation:
PMID:  17205313     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: The aim of our study was to review the imaging appearance of PXA, a rare and usually low-grade, astrocytic tumor that typically occurs in young adults. METHODS: The clinical presentation, location and imaging findings on CT (n = 15) and MR (n = 18) of 24 pathologically confirmed PXA were retrospectively reviewed. Two morphologic patterns were defined according to imaging features. The Mann-Whitney U-test was used for statistical analysis of the data. RESULTS: All the neoplasms were supratentorial and superficial in location with obvious leptomeningeal contact in 22 patients, although leptomeningeal enhancement was demonstrated in only 3. Common locations were temporal (42%), frontal (33%) and parietal (21%), and more than one lobe was involved in 21% of patients. On CT without contrast enhancement, PXA was an iso- or hypoattenuating mass, and calcification was seen in six tumors and inner table remodeling was seen in three patients younger than 12 years. On MR, the solid component of PXA was isointense relative to gray matter on T1-weighted images, hyperintense on T2-weighted images in more than 90% and enhanced intensely following intravenous contrast material administration. Cystic areas showed hyperintensity relative to CSF. Two imaging patterns were differentiated: first a cystic mass containing a mural nodule (70%) and second a predominantly solid mass that may show cystic changes (30%). CONCLUSION: The most consistent imaging features of PXA were a superficial location, leptomeningeal contact, and enhancement of the solid component. Apart from the classical PXA appearance of a cystic lesion with an enhancing mural nodule, a second pattern consisting of a predominantly solid mass was recognized.
Ana M Crespo-Rodríguez; James G Smirniotopoulos; Elisabeth J Rushing
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-01-05
Journal Detail:
Title:  Neuroradiology     Volume:  49     ISSN:  0028-3940     ISO Abbreviation:  Neuroradiology     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-29     Completed Date:  2007-06-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302751     Medline TA:  Neuroradiology     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  307-15     Citation Subset:  IM    
Servicio de Radiodiagnóstico, Hospital Universitario Clínica Puerta de Hierro, c/ San Martín de Porres, 4, Madrid 28035, Spain.
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MeSH Terms
Astrocytoma / diagnosis*,  radiography
Magnetic Resonance Imaging / methods*
Middle Aged
Retrospective Studies
Statistics, Nonparametric
Supratentorial Neoplasms / diagnosis*,  radiography
Tomography, X-Ray Computed / methods*

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