| MR-based molecular imaging of the brain: the next frontier. | |
| | |
MedLine Citation:
|
PMID: 20864520 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
In the foreseeable future, the MI field could greatly assist neuroradiologists. Reporter molecules provide information on specific molecular or cellular events that could not only aid diagnosis but potentially differentiate stages of disorders and treatments. To accomplish this, reporter molecules literally need to pass a barrier, the BBB, which is designed to repel nonessential molecules from the brain. Although this is not a trivial task, several transport systems could be tricked into guiding molecules into the brain. The noninvasive nature in conjunction with a wide availability makes MR imaging particularly suitable for longitudinal neurologic imaging studies. This review explains the principles of MR imaging contrast, delineates different types of reporter molecules, and describes strategies to transport reporters into the brain. It also discusses recent advances in MR imaging hardware, pulse sequences, the development of targeted reporter probes, and future directions of the MR neuroimaging field. |
| | |
Authors:
|
M E de Backer; R J A Nabuurs; M A van Buchem; L van der Weerd |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-23 |
Journal Detail:
|
Title: AJNR. American journal of neuroradiology Volume: 31 ISSN: 1936-959X ISO Abbreviation: AJNR Am J Neuroradiol Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-10-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8003708 Medline TA: AJNR Am J Neuroradiol Country: United States |
Other Details:
|
Languages: eng Pagination: 1577-83 Citation Subset: IM |
Affiliation:
|
Molecular Imaging Laboratories, Leiden, the Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Carotid intima-media thickness is greater but carotid plaque prevalence is lower in black compared w...
Next Document: Does current practice in the United States of carotid artery stent placement benefit asymptomatic oc...