Document Detail


The MPTP marmoset model of parkinsonism: a multi-purpose non-human primate model for neurodegenerative diseases.
MedLine Citation:
PMID:  20732446     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aging societies face an increasing prevalence of neurodegenerative disorders for which no cure exists. The paucity of relevant animal models that faithfully reproduce clinical and pathogenic features of neurodegenerative diseases is a major cause for the lack of effective therapies. Clinically distinct disorders, such as Alzheimer's and Parkinson's disease, are driven by overlapping pathogenic mechanisms that converge onto vulnerable neurons to ultimately cause abnormal clinical outcomes. These similarities, particularly in the early phases of neurodegeneration, might help identify appropriate animal model systems for studying of cell pathology. While reviewing some of the cellular mechanisms of disease progression, we discuss the MPTP-induced model of Parkinsonism in marmoset monkeys as a model system for construct, face and predictive validity in neurodegenerative studies.
Authors:
Ingrid H C H M Philippens; Bert A 't Hart; German Torres
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Publication Detail:
Type:  Journal Article     Date:  2010-08-21
Journal Detail:
Title:  Drug discovery today     Volume:  15     ISSN:  1878-5832     ISO Abbreviation:  Drug Discov. Today     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-30     Completed Date:  2011-06-07     Revised Date:  2012-06-28    
Medline Journal Info:
Nlm Unique ID:  9604391     Medline TA:  Drug Discov Today     Country:  England    
Other Details:
Languages:  eng     Pagination:  985-90     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Immunobiology, Biomedical Primate Research Centre, Lange Kleiweg 139, Rijswijk, The Netherlands. philippens@bprc.nl
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MeSH Terms
Descriptor/Qualifier:
Animals
Callithrix
Disease Models, Animal*
Humans
MPTP Poisoning*
Nerve Degeneration
Neurodegenerative Diseases*
Neurotoxins / toxicity
Parkinsonian Disorders*
Chemical
Reg. No./Substance:
0/Neurotoxins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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