Document Detail


MPI Cell Tracking: What Can We Learn from MRI?
MedLine Citation:
PMID:  22389573     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Magnetic resonance imaging (MRI) cell tracking has become an important non-invasive technique to interrogate the fate of cells upon transplantation. At least 6 clinical trials have been published at the end of 2010, all of which have shown that real-time monitoring of the injection procedure, initial engraftment, and short-term biodistribution of cells is critical to further advance the field of cellular therapeutics. In MRI cell tracking, cells are loaded with superparamagnetic iron oxide (SPIO) particles that provide an MRI contrast effect through microscopic magnetic field disturbances and dephasing of protons. Magnetic particle imaging (MPI) has recently emerged as a potential cellular imaging technique that promises to have several advantages over MRI, primarily linear quantification of cells, a higher sensitivity, and "hot spot" tracer identification without confounding background signal. Although probably not fully optimized, SPIO particles that are currently used as MRI contrast agent can be employed as MPI tracer. Initial studies have shown that cells loaded with SPIO particles can give a detectable MPI signal, encouraging further development of MPI cell tracking.
Authors:
Jeff W M Bulte; Piotr Walczak; Bernhard Gleich; Jürgen Weizenecker; Denis E Markov; Hans C J Aerts; Hans Boeve; Jörn Borgert; Michael Kuhn
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Proceedings - Society of Photo-Optical Instrumentation Engineers     Volume:  7965     ISSN:  1018-4732     ISO Abbreviation:  -     Publication Date:  2011  
Date Detail:
Created Date:  2012-3-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101290197     Medline TA:  Proc Soc Photo Opt Instrum Eng     Country:  -    
Other Details:
Languages:  ENG     Pagination:  79650z     Citation Subset:  -    
Affiliation:
Russell H. Morgan Dept. of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
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Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R01 DA026299-02//NIDA NIH HHS; R01 DA026299-03//NIDA NIH HHS

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