| MODY type diabetes: overview and recent findings. | |
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MedLine Citation:
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PMID: 22008132 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We present an update of knowledge on diabetes MODY (maturity onset diabetes of the young), including the recent molecular discoveries, and new diagnostic strategies. Considerable progress has been made in understanding the different molecular abnormalities that cause MODY and the phenotypic consequences resulting therefrom. MODY diabetes is very heterogeneous and is the most common form of monogenic diabetes. Its distribution is worldwide. MODY is an autosomal dominant diabetes mellitus, nonketotic and occurs at an early age (usually before 25 years). To date, at least seven genes are associated with MODY, with frequencies that differ from one population to another. Both 2 and 3 subtypes predominate, while other subtypes (1, 4, 5, 6 and 7) concern only a few families. Since its discovery in the sixties, studies have succeeded to fully clarify the epidemiological, molecular and clinical diagnosis of each subtype, to provide better care for patients. However, the subject of MODY has not yet revealed all its secrets. Indeed, it remains to identify other genes that are associated with MODY X. |
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Authors:
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Souhaïra Ben Khelifa; Ilhem Barboura; Azza Dandana; Selima Ferchichi; Abdelhedi Miled |
Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Annales de biologie clinique Volume: 69 ISSN: 0003-3898 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2984690R Medline TA: Ann Biol Clin (Paris) Country: - |
Other Details:
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Languages: ENG Pagination: 531-540 Citation Subset: - |
Affiliation:
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Laboratoire de biochimie, CHU Farhat Hached, Sousse, Tunisie. |
Vernacular Title:
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Le diabète de type MODY : revue générale et récentes découvertes. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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