Document Detail

MOCA is an integrator of the neuronal death signals that are activated by familial Alzheimer's disease-related mutants of amyloid beta precursor protein and presenilins.
MedLine Citation:
PMID:  22115042     Owner:  NLM     Status:  Publisher    
Death in cholinergic neurons in cerebral cortex and certain subcortical regions is linked to irreversible dementia relevant to Alzheimer's disease (AD). Although multiple studies have shown that expression of a familial AD (FAD)-linked amyloid beta precursor protein (APP) or a presenilin (PS) mutant, but not that of wild-type APP or PS, induced neuronal death by activating intracellular death signals, it remains to be addressed how these signals are interrelated and what the key molecule involving this process is. In this study, we show that the PS1-mediated (or possibly the PS2-mediated) signal is essential for the APP-mediated death in a gamma-secretase-independent manner and vice versa. MOCA (modifier of cell adhesion), originally identified as being a PS- and Rac1-binding protein, is a common downstream constituent of these neuronal death signals. The detailed molecular analysis indicates that MOCA is a key molecule of the AD-relevant neuronal death signals that links the PS-mediated death signal with the APP-mediated death signal at a point between Rac1 (or Cdc42) and ASK1.
Nobuyuki Tachi; Yuichi Hashimoto; Masaaki Matsuoka
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-24
Journal Detail:
Title:  The Biochemical journal     Volume:  -     ISSN:  1470-8728     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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