| MNU-induced carcinogenesis of rat mammary gland: effect of thyroid hormone on expression of retinoic acid receptors in tumours of mammary gland. | |
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MedLine Citation:
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PMID: 16219415 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The rat model of N-methyl-N-nitrosourea (MNU)-induced mammary carcinomas is well-established animal model for breast cancer. This study was carried out to investigate whether hypothyroid (thyroidectomy or PTU treatment) or hyperthyroid status of female rats would affect MNU-induced mammary carcinogenesis with specific focus on both retinoid and rexinoid receptor expression in mammary tumours. Application of PTU before and during MNU-induced mammary gland carcinogenesis yielded in a marked decrease of the number and volume of tumours per animal, however, there was no effect of hypothyroid state in thyroidectomized rats as well as hyperthyroid state concerning the number and volume of tumours. Mammary tumours of in euthyroid group of MNU animals showed that there was no tumour, in which all of subtypes of retinoid and rexinoid receptors were expressed. A different pattern of expression of retinoid or rexinoid receptors was found either in MNU-induced mammary carcinomas in both hypothyroid and hyperthyroid rats. |
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Authors:
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Dana Macejova; Zofia Radikova; Ladislav Macho; Jan Liska; Julius Brtko |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-10-10 |
Journal Detail:
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Title: Molecular and cellular endocrinology Volume: 244 ISSN: 0303-7207 ISO Abbreviation: Mol. Cell. Endocrinol. Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-11-21 Completed Date: 2006-03-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7500844 Medline TA: Mol Cell Endocrinol Country: Ireland |
Other Details:
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Languages: eng Pagination: 47-56 Citation Subset: IM |
Affiliation:
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Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlárska 3, 833 06 Bratislava, Slovak Republic. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinogens Female Gene Expression Hyperthyroidism Hypothyroidism / chemically induced Mammary Neoplasms, Experimental / chemically induced, genetics, metabolism* Methylnitrosourea Propylthiouracil RNA, Messenger / metabolism Rats Rats, Sprague-Dawley Receptors, Retinoic Acid / genetics, metabolism* Thyroid Hormones / physiology* Thyroidectomy |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens; 0/RNA, Messenger; 0/Receptors, Retinoic Acid; 0/Thyroid Hormones; 51-52-5/Propylthiouracil; 684-93-5/Methylnitrosourea |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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