| MMP-9 levels in elderly patients with cognitive dysfunction after carotid surgery. | |
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MedLine Citation:
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PMID: 20110172 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Approximately 25% of elderly patients scheduled for carotid endarterectomy (CEA) develop post-operative cognitive dysfunction (CD). We tested the hypothesis that the plasma levels of matrix metalloproteinase 9 (MMP-9) are predictive of moderate to severe CD after CEA. A total of 73 patients were prospectively enrolled in this Institutional Review Board-approved study. Plasma samples were obtained at baseline and day 1 post-surgery. We measured the plasma concentrations of both MMP-9 and its inhibitor, tissue inhibitor of metalloproteinases 1 (TIMP-1). We estimated the MMP-9 activity by calculating the MMP-9:TIMP-1 ratio. The cognitive performance day 1 post-surgery was quantified with z-scores, using a control group who were undergoing spinal surgery. The criteria used to define CD was performance of >or=1.5 standard deviations worse than the control group; approximately 19% of eligible patients developed CD. Compared to patients without CD, this group had both higher total (81.66+/-12.25 ng/mL versus [vs.] 43.18+/-4.44 ng/mL, p=0.005) and activity (0.88+/-0.24 ng/mL vs. 0.54+/-0.06 ng/mL, p=0.003) MMP-9 levels at baseline. All of the results were adjusted for age, diabetes and neurovascular symptoms. |
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Authors:
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John G Gaudet; Gene T Yocum; Susie S Lee; Anna Granat; Maya Mikami; E Sander Connolly; Eric J Heyer |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-01-27 |
Journal Detail:
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Title: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia Volume: 17 ISSN: 1532-2653 ISO Abbreviation: J Clin Neurosci Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-08 Completed Date: 2010-06-14 Revised Date: 2013-05-31 |
Medline Journal Info:
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Nlm Unique ID: 9433352 Medline TA: J Clin Neurosci Country: Scotland |
Other Details:
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Languages: eng Pagination: 436-40 Citation Subset: IM |
Copyright Information:
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(c) 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Anesthesiology, New York Presbyterian Hospital, Columbia University, 620 West 168th Street, New York, New York 10032, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cognition Disorders / enzymology*, etiology Endarterectomy, Carotid / adverse effects* Female Humans Male Matrix Metalloproteinase 9 / blood* Middle Aged Neuropsychological Tests Postoperative Complications / enzymology*, etiology Tissue Inhibitor of Metalloproteinase-1 / blood |
| Grant Support | |
ID/Acronym/Agency:
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R01 AG017604-06/AG/NIA NIH HHS; R01 AG17604/AG/NIA NIH HHS; T32 GM008464/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Tissue Inhibitor of Metalloproteinase-1; EC 3.4.24.35/Matrix Metalloproteinase 9 |
| Comments/Corrections | |
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