Document Detail

MMP-9 levels in elderly patients with cognitive dysfunction after carotid surgery.
MedLine Citation:
PMID:  20110172     Owner:  NLM     Status:  MEDLINE    
Approximately 25% of elderly patients scheduled for carotid endarterectomy (CEA) develop post-operative cognitive dysfunction (CD). We tested the hypothesis that the plasma levels of matrix metalloproteinase 9 (MMP-9) are predictive of moderate to severe CD after CEA. A total of 73 patients were prospectively enrolled in this Institutional Review Board-approved study. Plasma samples were obtained at baseline and day 1 post-surgery. We measured the plasma concentrations of both MMP-9 and its inhibitor, tissue inhibitor of metalloproteinases 1 (TIMP-1). We estimated the MMP-9 activity by calculating the MMP-9:TIMP-1 ratio. The cognitive performance day 1 post-surgery was quantified with z-scores, using a control group who were undergoing spinal surgery. The criteria used to define CD was performance of >or=1.5 standard deviations worse than the control group; approximately 19% of eligible patients developed CD. Compared to patients without CD, this group had both higher total (81.66+/-12.25 ng/mL versus [vs.] 43.18+/-4.44 ng/mL, p=0.005) and activity (0.88+/-0.24 ng/mL vs. 0.54+/-0.06 ng/mL, p=0.003) MMP-9 levels at baseline. All of the results were adjusted for age, diabetes and neurovascular symptoms.
John G Gaudet; Gene T Yocum; Susie S Lee; Anna Granat; Maya Mikami; E Sander Connolly; Eric J Heyer
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-01-27
Journal Detail:
Title:  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia     Volume:  17     ISSN:  1532-2653     ISO Abbreviation:  J Clin Neurosci     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-08     Completed Date:  2010-06-14     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  9433352     Medline TA:  J Clin Neurosci     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  436-40     Citation Subset:  IM    
Copyright Information:
(c) 2009 Elsevier Ltd. All rights reserved.
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MeSH Terms
Cognition Disorders / enzymology*,  etiology
Endarterectomy, Carotid / adverse effects*
Matrix Metalloproteinase 9 / blood*
Middle Aged
Neuropsychological Tests
Postoperative Complications / enzymology*,  etiology
Tissue Inhibitor of Metalloproteinase-1 / blood
Grant Support
R01 AG017604/AG/NIA NIH HHS; R01 AG017604-06/AG/NIA NIH HHS; R01 AG17604/AG/NIA NIH HHS; T32 GM008464/GM/NIGMS NIH HHS
Reg. No./Substance:
0/Tissue Inhibitor of Metalloproteinase-1; EC Metalloproteinase 9

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