Document Detail

MMP-2 is involved in synaptic remodeling after cochlear lesion.
MedLine Citation:
PMID:  20173666     Owner:  NLM     Status:  MEDLINE    
Lesion-induced neuroplasticity, including fiber degeneration, axonal growth, and synaptogenesis, involves dynamical changes of the extracellular matrix. We discovered that the matrix metalloprotease-2 (MMP-2), a major actor in extracellular matrix recomposition, is changed in distribution and increased in amount in the ventral cochlear nucleus after unilateral cochlear ablation. There was a remarkable coincidence of MMP-2 accumulation and GAP-43 expression in time and space. We obtained evidence indicating that MMP-2 is delivered to regions of emerging GAP-43 positive synaptic endings by postsynaptic neurons as well as by adjoining astrocytes. These results indicate a major role of MMP-2 in lesion-induced remodeling of central auditory networks and suggest a cooperativity with GAP-43-directed axonal outgrowth and synaptogenesis.
Michaela Fredrich; Robert-Benjamin Illing
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  21     ISSN:  1473-558X     ISO Abbreviation:  Neuroreport     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-11     Completed Date:  2010-06-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  324-7     Citation Subset:  IM    
Neurobiological Research Laboratory, Department of Otorhinolaryngology, University of Freiburg, Freiburg, Germany.
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MeSH Terms
Astrocytes / physiology
Axons / physiology
Cochlea / injuries,  physiopathology*
Fluorescent Antibody Technique
GAP-43 Protein / metabolism*
Matrix Metalloproteinase 2 / metabolism*
Neuronal Plasticity / physiology*
Neurons / physiology*
Rats, Wistar
Synapses / physiology*
Time Factors
Reg. No./Substance:
0/GAP-43 Protein; EC Metalloproteinase 2; EC protein, rat

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