Document Detail

MMP-2 Expression in Skeletal Muscle after Strength Training.
MedLine Citation:
PMID:  22095325     Owner:  NLM     Status:  Publisher    
The aim of this study was to assess the effects of resistance training on ladders (RTL) on MMP-2 expression and blood lactate concentration [La-]. 30 male (3 months of age), albino rats were divided into 3 groups: sedentary control (SC, n=10), low resistance exercise training (Low-IntRT, n=10) and high-intensive exercise training (High-IntRT, n=10). Animals of High-IntRT were submitted to a progressively increasing overload in relation to body weight until exhaustion, while the Low-IntRT group performed the same exercise regimen with no external load. The program had a frequency of 3 times per week over 8 weeks. MMP-2 expression of tibialis anterior muscle and [La-] were measured. While there was a significant increase of MMP-2 (pro-form) in both groups, only High-IntRT significantly increased MMP-2 in active-form (p<0.05). Both trained groups exhibited an increase in [La-] when compared to controls, however, the increase in [La-] was significantly higher in the High-IntRT compared to Low-IntRT (p<0.05). Strong correlation was found between MMP-2 (active form) and [La-] in High-IntRT (r=0.91). RTL in using low and high-intensity exercise can serve as a model to demonstrate different responses of MMP-2 expression in an animal model. It appears active form expression of MMP-2 is modulated by exercise intensity.
A P L Deus; D Bassi; R P Simões; C R Oliveira; V Baldissera; R de Cássia Marqueti; H S S Araujo; R Arena; A Borghi-Silva
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-17
Journal Detail:
Title:  International journal of sports medicine     Volume:  -     ISSN:  1439-3964     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
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