| MMP-2 Expression in Skeletal Muscle after Strength Training. | |
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MedLine Citation:
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PMID: 22095325 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The aim of this study was to assess the effects of resistance training on ladders (RTL) on MMP-2 expression and blood lactate concentration [La-]. 30 male (3 months of age), albino rats were divided into 3 groups: sedentary control (SC, n=10), low resistance exercise training (Low-IntRT, n=10) and high-intensive exercise training (High-IntRT, n=10). Animals of High-IntRT were submitted to a progressively increasing overload in relation to body weight until exhaustion, while the Low-IntRT group performed the same exercise regimen with no external load. The program had a frequency of 3 times per week over 8 weeks. MMP-2 expression of tibialis anterior muscle and [La-] were measured. While there was a significant increase of MMP-2 (pro-form) in both groups, only High-IntRT significantly increased MMP-2 in active-form (p<0.05). Both trained groups exhibited an increase in [La-] when compared to controls, however, the increase in [La-] was significantly higher in the High-IntRT compared to Low-IntRT (p<0.05). Strong correlation was found between MMP-2 (active form) and [La-] in High-IntRT (r=0.91). RTL in using low and high-intensity exercise can serve as a model to demonstrate different responses of MMP-2 expression in an animal model. It appears active form expression of MMP-2 is modulated by exercise intensity. |
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Authors:
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A P L Deus; D Bassi; R P Simões; C R Oliveira; V Baldissera; R de Cássia Marqueti; H S S Araujo; R Arena; A Borghi-Silva |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-17 |
Journal Detail:
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Title: International journal of sports medicine Volume: - ISSN: 1439-3964 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8008349 Medline TA: Int J Sports Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© Georg Thieme Verlag KG Stuttgart · New York. |
Affiliation:
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Physiotherapy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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