Document Detail


MMM: a sequence-to-structure alignment protocol.
MedLine Citation:
PMID:  16928737     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
MOTIVATION: Accurate alignment of a target sequence to a template structure continues to be a bottleneck in producing good quality comparative protein structure models. RESULTS: Multiple Mapping Method (MMM) is a comparative protein structure modeling server with an emphasis on a novel alignment optimization protocol. MMM takes inputs from five profile-to-profile based alignment methods. The alternatively aligned regions from the input alignment set are combined according to their fit in the structural environment of the template structure. The resulting, optimally spliced MMM alignment is used as input to an automated comparative modeling module to produce a full atom model. AVAILABILITY: The MMM server is freely accessible at http://www.fiserlab.org/servers/mmm
Authors:
Brajesh K Rai; Carlos J Madrid-Aliste; J Eduardo Fajardo; András Fiser
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2006-08-23
Journal Detail:
Title:  Bioinformatics (Oxford, England)     Volume:  22     ISSN:  1367-4811     ISO Abbreviation:  Bioinformatics     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-25     Completed Date:  2006-12-11     Revised Date:  2009-11-04    
Medline Journal Info:
Nlm Unique ID:  9808944     Medline TA:  Bioinformatics     Country:  England    
Other Details:
Languages:  eng     Pagination:  2691-2     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Seaver Center for Bioinformatics, Albert Einstein College of Medicine 1300 Morris Park Avenue, Bronx, NY 10461, USA.
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MeSH Terms
Descriptor/Qualifier:
Algorithms*
Amino Acid Sequence
Computer Simulation
Internet
Models, Molecular*
Molecular Sequence Data
Protein Structure, Secondary
Sequence Analysis, Protein / methods*
Software*
Grant Support
ID/Acronym/Agency:
GM62519-04/GM/NIGMS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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