Document Detail

MLR-blocking antibodies are directed against alloantigens expressed on syncytiotrophoblasts.
MedLine Citation:
PMID:  2534038     Owner:  NLM     Status:  MEDLINE    
In this study, the reactivity of mixed lymphocyte reaction-blocking antibodies toward trophoblasts was investigated. Nineteen sera that had a significant level of MLR-blocking effect were obtained from normal pregnant women and from primary habitual aborters after immunotherapy. The blocking effects of these sera were studied before and after absorption with syncytiotrophoblast plasma membrane (STPM) from the respective mothers' placenta (autologous) as an experimental group and from unrelated mothers' placenta (allogeneic) as a control. The HLA types of cord blood lymphocytes corresponding to ten of these STPM were then determined. In the study with the 11 normal pregnancy sera, the blocking effect of every serum was partially removed by autologous STPM absorption. This revealed a significant difference between the preabsorption and postabsorption MLR-blocking effect. Nevertheless, absorption by the allogeneic STPM either partially removed or did not remove the blocking effect. Furthermore, there was a statistically significant difference in the elimination of the MLR-blocking effect between the autologous STPM and the allogeneic STPM. Studies with the sera from the immunized aborters revealed similar results. There was no statistically significant difference in the elimination of the antibodies between absorption with autologous and with allogeneic STPM. In these habitual aborters' sera, comparison of paternal stimulator and cord blood lymphocytes HLA types showed that the positive allogeneic STPM absorptions could not be explained sufficiently by coincidence of HLA types. Further studies are needed to determine whether the alloantigens are HLA-linked or not.
S Goto; K Takakuwa; K Kanazawa; S Takeuchi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  21     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1990-04-26     Completed Date:  1990-04-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  50-3     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Niigata University School of Medicine, Japan.
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MeSH Terms
Abortion, Habitual / immunology,  therapy
Binding, Competitive
Fetal Blood / immunology
HLA Antigens
Immunoglobulin G / metabolism
Immunosorbent Techniques
Lymphocyte Culture Test, Mixed
Trophoblasts / immunology*
Reg. No./Substance:
0/HLA Antigens; 0/Immunoglobulin G; 0/Isoantibodies; 0/Isoantigens

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