Document Detail

MLL amplification in myeloid malignancies: clinical, molecular, and cytogenetic findings.
MedLine Citation:
PMID:  12034519     Owner:  NLM     Status:  MEDLINE    
Structural rearrangements involving the MLL gene at 11q23 are common recurring abnormalities in de novo and therapy-related hematologic disorders. MLL rearrangement most often results from translocation or partial tandem duplication, although recent published reports suggest a different mechanism by which MLL might participate in leukemogenesis: MLL amplification. We report two patients with myeloid disorders who showed amplification of MLL at diagnosis and who, like the majority of reported cases, had an older age at onset and on aggressive clinical course. Additionally, we summarize the salient clinical, cytogenetic and molecular findings of the 29 other cases of MLL amplification that have thus far been reported.
Michelle Dolan; Ronald C McGlennen; Betsy Hirsch
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  134     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-05-29     Completed Date:  2002-06-14     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  93-101     Citation Subset:  IM    
Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA.
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MeSH Terms
Aged, 80 and over
Child, Preschool
Chromosome Aberrations
DNA-Binding Proteins / genetics*
Gene Amplification*
In Situ Hybridization, Fluorescence
Leukemia, Myeloid / genetics*
Middle Aged
Myeloid-Lymphoid Leukemia Protein
Transcription Factors*
Reg. No./Substance:
0/DNA-Binding Proteins; 0/MLL protein, human; 0/Transcription Factors; 149025-06-9/Myeloid-Lymphoid Leukemia Protein

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