| Is MK2 (mitogen-activated protein kinase-activated protein kinase 2) the key for understanding post-transcriptional regulation of gene expression? | |
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MedLine Citation:
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PMID: 12440954 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The phenotype of mitogen-activated protein kinase-activated protein kinase-2 (MK2) knockout mice revealed the essential role of this enzyme in post-transcriptional regulation of lipopolysaccharide-induced expression of cytokines such as tumour necrosis factor (TNF)-alpha, interleukin-6 and interferon-gamma, at the level of mRNA stability and translation. In the case of TNF-alpha, this regulation depends on the AU-rich element in TNF-alpha mRNA. In addition to cytokine expression, MK2 is also essential for cell migration in vitro. Although the role of MK2 in cytokine expression depends mainly on catalytic activity, its role in cell migration is also dependent on a proline-rich N-terminal motif. However, the molecular mechanisms involved and the relevant protein targets for MK2 are not completely defined. Here we discuss the possible mechanisms by which two potential target proteins of MK2, small heat-shock protein 25/27 (Hsp25/27) and tristetraprolin, could contribute to our understanding of the above regulation. |
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Authors:
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A Kotlyarov; M Gaestel |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Biochemical Society transactions Volume: 30 ISSN: 0300-5127 ISO Abbreviation: Biochem. Soc. Trans. Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-11-20 Completed Date: 2003-06-10 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7506897 Medline TA: Biochem Soc Trans Country: England |
Other Details:
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Languages: eng Pagination: 959-63 Citation Subset: IM |
Affiliation:
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Medical School Hannover, Institute of Biochemistry, Carl-Neuberg-Strasse 1, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals DNA-Binding Proteins* Gene Expression Regulation* Heat-Shock Proteins* Immediate-Early Proteins / metabolism Intracellular Signaling Peptides and Proteins Mice Mice, Knockout Mitogen-Activated Protein Kinases / metabolism, physiology* Models, Biological Neoplasm Proteins / metabolism Phenotype Protein Biosynthesis Protein Kinases* Protein-Serine-Threonine Kinases RNA Processing, Post-Transcriptional* RNA, Messenger / metabolism Tristetraprolin p38 Mitogen-Activated Protein Kinases |
| Chemical | |
Reg. No./Substance:
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0/DNA-Binding Proteins; 0/Heat-Shock Proteins; 0/Hspb1 protein, mouse; 0/Immediate-Early Proteins; 0/Intracellular Signaling Peptides and Proteins; 0/Neoplasm Proteins; 0/RNA, Messenger; 0/Tristetraprolin; 0/Zfp36 protein, mouse; EC 2.7.-/Protein Kinases; EC 2.7.1.-/MAP-kinase-activated kinase 2; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.24/Mitogen-Activated Protein Kinases; EC 2.7.11.24/p38 Mitogen-Activated Protein Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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