| MK-927: a topically effective carbonic anhydrase inhibitor in patients. | |
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MedLine Citation:
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PMID: 2667509 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects on intraocular pressure of the novel topical carbonic anhydrase inhibitor MK-927 were investigated for the first time in patients. Three drops of 2% MK-927 was administered in a two-center, double-masked, randomized, placebo-controlled, two-period crossover study in 25 patients with bilateral primary open angle glaucoma or ocular hypertension. At 4.5 hours after the dose, MK-927-treated eyes demonstrated a peak mean change of -7.7 mm Hg from a mean intraocular pressure of 27.8 mm Hg immediately before the dose; this compares with a change of -3.9 mm Hg from a mean intraocular pressure of 28.2 mm Hg when the same eyes were treated with placebo. The peak mean percent change in intraocular pressure in eyes treated with MK-927 was -26.7% at 6 hours after the dose compared with a change of -13.7% after treatment with placebo. No contralateral effect on intraocular pressure due to MK-927 was observed. |
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Authors:
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A M Bron; E A Lippa; H M Hofmann; B I Feicht; J G Royer; F L Brunner-Ferber; D L Panebianco; H A Von Denffer |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Archives of ophthalmology Volume: 107 ISSN: 0003-9950 ISO Abbreviation: Arch. Ophthalmol. Publication Date: 1989 Aug |
Date Detail:
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Created Date: 1989-09-01 Completed Date: 1989-09-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7706534 Medline TA: Arch Ophthalmol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1143-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Ophthalmology, Besançon (France), University. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Carbonic Anhydrase Inhibitors / administration & dosage, therapeutic use* Clinical Trials as Topic Double-Blind Method Eye Color Female Glaucoma, Open-Angle / drug therapy* Humans Intraocular Pressure / drug effects Male Middle Aged Ocular Hypertension / drug therapy* Ophthalmic Solutions Placebos Random Allocation Sulfonamides / administration & dosage, therapeutic use* Thiophenes / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Carbonic Anhydrase Inhibitors; 0/Ophthalmic Solutions; 0/Placebos; 0/Sulfonamides; 0/Thiophenes; 123291-07-6/sezolamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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