Document Detail

MK-927: a topically effective carbonic anhydrase inhibitor in patients.
MedLine Citation:
PMID:  2667509     Owner:  NLM     Status:  MEDLINE    
The effects on intraocular pressure of the novel topical carbonic anhydrase inhibitor MK-927 were investigated for the first time in patients. Three drops of 2% MK-927 was administered in a two-center, double-masked, randomized, placebo-controlled, two-period crossover study in 25 patients with bilateral primary open angle glaucoma or ocular hypertension. At 4.5 hours after the dose, MK-927-treated eyes demonstrated a peak mean change of -7.7 mm Hg from a mean intraocular pressure of 27.8 mm Hg immediately before the dose; this compares with a change of -3.9 mm Hg from a mean intraocular pressure of 28.2 mm Hg when the same eyes were treated with placebo. The peak mean percent change in intraocular pressure in eyes treated with MK-927 was -26.7% at 6 hours after the dose compared with a change of -13.7% after treatment with placebo. No contralateral effect on intraocular pressure due to MK-927 was observed.
A M Bron; E A Lippa; H M Hofmann; B I Feicht; J G Royer; F L Brunner-Ferber; D L Panebianco; H A Von Denffer
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  107     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-09-01     Completed Date:  1989-09-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1143-6     Citation Subset:  AIM; IM    
Department of Ophthalmology, Besançon (France), University.
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MeSH Terms
Aged, 80 and over
Carbonic Anhydrase Inhibitors / administration & dosage,  therapeutic use*
Clinical Trials as Topic
Double-Blind Method
Eye Color
Glaucoma, Open-Angle / drug therapy*
Intraocular Pressure / drug effects
Middle Aged
Ocular Hypertension / drug therapy*
Ophthalmic Solutions
Random Allocation
Sulfonamides / administration & dosage,  therapeutic use*
Thiophenes / administration & dosage,  therapeutic use*
Reg. No./Substance:
0/Carbonic Anhydrase Inhibitors; 0/Ophthalmic Solutions; 0/Placebos; 0/Sulfonamides; 0/Thiophenes; 123291-07-6/sezolamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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