Document Detail


The MINERVA study design and rationale: a controlled randomized trial to assess the clinical benefit of minimizing ventricular pacing in pacemaker patients with atrial tachyarrhythmias.
MedLine Citation:
PMID:  18760124     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Dual-chamber (DDD) pacing has generally been regarded as "physiologic pacing" and therefore expected to be superior to ventricular pacing. Major randomized trials have so far failed to demonstrate significant reductions in the incidences of mortality, stroke, and heart failure. It has been shown that unnecessary ventricular pacing in patients with sinus node dysfunction or only intermittent atrioventricular block is associated with ventricular desynchronization and increased risk of atrial tachyarrhythmias (ATA). METHODS: The MINimizE Right Ventricular pacing to prevent Atrial fibrillation and heart failure (MINERVA) study is a prospective, multi-center, randomized, international, single-blind, controlled trial designed to determine whether physiologic pacing through the managed ventricular pacing (MVP) algorithm combined with preventive atrial pacing (PAP) and atrial antitachycardia pacing (ATP) is superior to standard DDD pacing in terms of 2-year reduction in death, permanent ATA, and cardiovascular hospitalizations. Patients with standard class I or II indications for permanent DDD pacing and history of ATA will receive a Medtronic EnRhythm implantable pacemaker (Medtronic, Minneapolis, MN). After a 1-month run-in period, patients will be randomized in a 1:1:1 manner to the DDD (control group, all OFF), the DDDRP (MVP + PAP + ATP ON), and the MVP group (only MVP ON). Up to 1,300 patients will be included in approximately 70 centers in Europe, the Middle East, and Asia. CONCLUSIONS: The MINERVA study will make an important contribution to the management of patients with paroxysmal ATA and accepted indications for dual-chamber pacemaker implantation by determining whether physiologic pacing combined with PAP and ATP is superior to standard DDD pacing in terms of reduction of mortality, incidence of permanent ATA, and cardiovascular hospitalizations.
Authors:
Reinhard C Funck; Giuseppe Boriani; Antonis S Manolis; Helmut Püererfellner; Luis Mont; Raymond Tukkie; André Pisapia; Carsten W Israel; Nicoletta Grovale; Andrea Grammatico; Luigi Padeletti;
Related Documents :
6195604 - Thermoplastic polyurethanes as insulating materials for long-life cardiac pacing leads.
7359934 - Follow-up experience with permanent endocardial tined pacemaker electrodes.
17300304 - Temporary epicardial pacing after cardiac surgery: a practical review: part 1: general ...
322484 - Simultaneous left ventricular echocardiography and aortic blood velocity during rapid r...
21804774 - Cardioembolic stroke: clinical features, specific cardiac disorders and prognosis.
1568294 - Isolation, characterization, and localization of cardiac collagen type vi. associations...
Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American heart journal     Volume:  156     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-01     Completed Date:  2008-09-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  445-51     Citation Subset:  AIM; IM    
Affiliation:
Philipps University Marburg, Marburg, Germany. funck@mailer.uni-marburg.de
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00262119
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Atrial Fibrillation / prevention & control
Atrial Function*
Cardiac Pacing, Artificial / methods*
Cardiovascular Diseases / prevention & control,  therapy
Hospitalization / statistics & numerical data
Humans
Incidence
Research Design*
Single-Blind Method
Tachycardia / epidemiology,  mortality,  physiopathology*,  therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Safety and efficacy of sertraline for depression in patients with CHF (SADHART-CHF): a randomized, d...
Next Document:  The Heart Failure Adherence and Retention Trial (HART): design and rationale.