| The MIF -173G/C polymorphism and risk of childhood acute lymphoblastic leukemia in a Chinese population. | |
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MedLine Citation:
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PMID: 20447688 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Migration inhibitory factor (MIF) has recently been defined as a novel pro-tumorigenic factor that promotes cell proliferation, migration, and invasion. The MIF -173C allele results in increased MIF promoter activity and is associated with a higher serum MIF level. We hypothesized that this polymorphism may contribute to childhood acute lymphoblastic leukemia (ALL) susceptibility. We genotyped the MIF -173G/C polymorphism (rs755622) in 346 ALL cases and 516 cancer-free controls in a Chinese population and found that the variant genotype GC and the combined genotypes GC/CC were associated with a significantly higher risk of childhood ALL [adjusted odds ratio (OR)=1.39, 95% confidence interval (CI)=1.01-1.93 for GC and adjusted OR=1.38, 95% CI=1.01-1.89 for GC/CC]. In addition, we found that the increased risk was more pronounced among high-risk ALL and B-phenotype ALL patients. Our results suggest that the MIF -173G/C polymorphism is involved in the etiology of childhood ALL and is a potential candidate gene for determining cancer susceptibility. Further validations in other populations are warranted. |
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Authors:
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Yao Xue; Hongyan Xu; Liucheng Rong; Qin Lu; Jie Li; Na Tong; Meilin Wang; Zhengdong Zhang; Yongjun Fang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-05 |
Journal Detail:
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Title: Leukemia research Volume: 34 ISSN: 1873-5835 ISO Abbreviation: Leuk. Res. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-08-27 Completed Date: 2010-09-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7706787 Medline TA: Leuk Res Country: England |
Other Details:
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Languages: eng Pagination: 1282-6 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Hematology and Oncology, The Affiliated Nanjing Children's Hospital of Nanjing Medical University, No. 72 Guanzhou Road, Nanjing 210008, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Asian Continental Ancestry Group / genetics* Child Child, Preschool Female Genetic Predisposition to Disease Humans Infant Intramolecular Oxidoreductases / genetics*, physiology Macrophage Migration-Inhibitory Factors / genetics*, physiology Male Polymorphism, Single Nucleotide* Precursor Cell Lymphoblastic Leukemia-Lymphoma / etiology, genetics* Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Macrophage Migration-Inhibitory Factors; EC 5.3.-/Intramolecular Oxidoreductases; EC 5.3.2.1/MIF protein, human |
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