Document Detail

MICA exon 5 microsatellite typing by DNA heteroduplex analysis: a new polymorphism in the transmembrane region.
MedLine Citation:
PMID:  9550334     Owner:  NLM     Status:  MEDLINE    
MICA (MHC class I chain-related gene A) is localized 47 kb upstream from HLA-B on the short arm of chromosome 6. It has been postulated that MICA protein folds similarly to the class I chain and may have the capacity to bind short ligands. Short tandem repeats (STR) within the transmembrane (TM) region of this gene have been described and five alleles consisting of 4 to 9 GCT codons, each encoding an alanine residue have been defined. We have applied DNA heteroduplex analysis to type MICA trinucleotide repeats in order to develop a simple and reliable method for their identification. This approach allowed the characterization of all MICA alleles. Moreover, a new polymorphism within the TM region was identified.
L R Vitiani; I Potolicchio; M D'Amato; O R Baricordi; R Sorrentino
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Tissue antigens     Volume:  51     ISSN:  0001-2815     ISO Abbreviation:  Tissue Antigens     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-06-09     Completed Date:  1998-06-09     Revised Date:  2012-02-22    
Medline Journal Info:
Nlm Unique ID:  0331072     Medline TA:  Tissue Antigens     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  309-11     Citation Subset:  IM    
Dept. of Cell Biology and Development, University of Rome La Sapienza, Roma, Italy.
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MeSH Terms
Cell Line
Histocompatibility Antigens Class I / genetics*
Microsatellite Repeats*
Nucleic Acid Heteroduplexes*
Polymorphism, Genetic*
Grant Support
Reg. No./Substance:
0/Histocompatibility Antigens Class I; 0/MHC class I-related chain A; 0/Nucleic Acid Heteroduplexes; 9007-49-2/DNA

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