Document Detail

MIBG scintigraphy for differentiating Parkinson's disease with autonomic dysfunction from Parkinsonism-predominant multiple system atrophy.
MedLine Citation:
PMID:  19514077     Owner:  NLM     Status:  MEDLINE    
Parkinson's disease (PD) with autonomic dysfunction is difficult to differentiate from Parkinsonism-predominant multiple system atrophy (MSA-p). This study aimed to analyze the validity of MIBG scintigraphy for PD with autonomic dysfunction and MSA-p. Thirty-nine patients (PD: 27 patients, MSA-p type: 12) and 12 age-matched controls were prospectively enrolled and underwent MIBG scintigraphy and autonomic function test (AFT). We separately calculated early and delayed heart-to-mediastinal (H/M) ratio and washout rates (WRs). AFT was composed of sympathetic skin reflex and parasympathetic tests based on heart rate variability. Abnormal AFT was observed in 17 (63%) of PD and 10 (83%) of MSA-p. On comparing PD with abnormal AFT with MSA-p, either the early or delayed H/M ratio in PD was not different from that in MSA-p (P > 0.05). Only the WR could differentiate PD with abnormal AFT from MSA-p (47.07 +/- 57.48 vs. 31.39 +/- 31.52, respectively) (P = 0.026). According to the results, WR may be more useful than the early and delayed H/M ratio to distinguish MSA-p from PD with abnormal AFT. Furthermore, the MIBG uptake did not reflect the disease duration or severity.
Eun Joo Chung; Won Yong Lee; Won Tae Yoon; Byeong Joon Kim; Gyeong Han Lee
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Publication Detail:
Type:  Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  24     ISSN:  1531-8257     ISO Abbreviation:  Mov. Disord.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-09-01     Completed Date:  2010-01-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1650-5     Citation Subset:  IM    
Copyright Information:
2009 Movement Disorder Society.
Department of Neurology, Inje University Pusan Baik Hospital, Pusan, Korea.
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MeSH Terms
3-Iodobenzylguanidine / diagnostic use*
Adenosine / diagnostic use
Autonomic Nervous System Diseases / etiology*
Diagnosis, Differential
Galvanic Skin Response
Heart / radionuclide imaging
Heart Rate
Iodine Radioisotopes / diagnostic use*
Middle Aged
Multiple System Atrophy / complications,  diagnosis,  radionuclide imaging*
Parkinson Disease / complications,  diagnosis,  radionuclide imaging*
Parkinsonian Disorders / diagnosis,  etiology,  radionuclide imaging*
Predictive Value of Tests
Prospective Studies
Radiopharmaceuticals / diagnostic use*
Sensitivity and Specificity
Sympathetic Fibers, Postganglionic / physiopathology
Tomography, Emission-Computed, Single-Photon*
Valsalva Maneuver
Reg. No./Substance:
0/Iodine Radioisotopes; 0/Radiopharmaceuticals; 58-61-7/Adenosine; 77679-27-7/3-Iodobenzylguanidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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