| MIB-1 labeling index correlated with magnetic resonance imaging detected tumor volume doubling time in pituitary adenoma. | |
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MedLine Citation:
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PMID: 20231369 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to evaluate whether MIB-1 labeling index (LI) could be used to predict growth velocity of residual pituitary adenomas after surgery. MATERIALS AND METHODS: One hundred and sixty pituitary adenomas which had not received other treatment modality except for surgery were collected. Each of them had at least two post-operative magnetic resonance imaging (MRI) studies with an interval of at least 1 month apart. Tumor volume doubling time (TVDT) was calculated for those in which volume increased. RESULTS: Post-operative tumor progression was noted in 54 (33.8%) cases, of which 39 (72.2%) cases were non-functioning adenomas. The MIB-1 LIs of the functioning and non-functioning adenomas were not significantly different. The median TVDT of these 54 cases was 34.6 months. The mean and median MIB-1 LI were 2.7 and 1.1 respectively (range 0.4-20.6). The MIB-1 LI was significantly correlated with log(2)(TVDT) (r=-0.363, P=0.007); when LI was <0.8, the TVDT of 90.5% cases was >or= 2 years. CONCLUSIONS: Only one-third of the pituitary adenomas progressed after surgery, and their MIB-1 LIs were generally low. The MIB-1 LI was significantly correlated with the MRI detected TVDT of post-operative residual pituitary adenomas. |
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Authors:
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Chih-Yi Hsu; Wan-Yuo Guo; Chen-Ping Chien; Donald Ming-Tak Ho |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-15 |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: 162 ISSN: 1479-683X ISO Abbreviation: Eur. J. Endocrinol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-21 Completed Date: 2010-06-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 1027-33 Citation Subset: IM |
Affiliation:
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Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, 201 Shih-Pai Road, Section 2, Taipei, Taiwan, ROC. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Humans Magnetic Resonance Imaging Male Middle Aged Mitotic Index* Neoplasm Recurrence, Local / pathology*, surgery Pituitary Neoplasms / pathology*, surgery Prognosis Tumor Burden |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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