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The MHC2TA gene polymorphisms are not associated with restenosis after coronary stenting in Mexican patients.
MedLine Citation:
PMID:  23021357     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: The aim of this study was to test for association between MHC2TA gene polymorphisms and risk for restenosis after coronary stent placement in a group of Mexican patients.
METHODS: The MHC2TA-168A>G (rs3087456), 1614C>G (rs4774), and 2536G>A (rs2229320) single nucleotide polymorphisms were genotyped using 5' exonuclease TaqMan genotyping assays in a group of 202 patients, who underwent coronary artery stenting. Basal and procedure coronary angiography were analyzed, looking for angiographic predictors of restenosis and follow-up angiography was performed to screen for binary restenosis.
RESULTS: The results obtained in this study showed that the frequency of the three polymorphisms studied was similar in patients with and without restenosis. Univariate analysis showed that the use of drug-eluting stent (DES) reduces the risk of developing restenosis (p<0.001, OR=0.26). In contrast, the diameter<2.5mm of the stent and bifurcations increased the risk of developing restenosis (p=0.049, OR=1.74 and p=0.041, OR=1.8).
CONCLUSION: The present study suggests that the MHC2TA polymorphisms are not involved in the risk of developing restenosis after coronary stent placement.
Hilda Delgadillo; Gilberto Vargas-Alarcón; Omar Gómez-Monterrosas; Nancy Martínez-Rodríguez; Silvestre Ramírez-Fuentes; Silvia Carrillo-Sánchez; Marco Antonio Peña-Duque; Marco Antonio Martínez-Ríos; Oscar Pérez-Méndez; José Manuel Fragoso
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Publication Detail:
Type:  Journal Article     Date:  2012-09-14
Journal Detail:
Title:  Archivos de cardiología de México     Volume:  82     ISSN:  1405-9940     ISO Abbreviation:  Arch Cardiol Mex     Publication Date:    2012 Jul-Sep
Date Detail:
Created Date:  2012-10-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101126728     Medline TA:  Arch Cardiol Mex     Country:  Mexico    
Other Details:
Languages:  eng     Pagination:  208-13     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Instituto Nacional de Cardiología Ignacio Chávez. Published by Masson Doyma México S.A. All rights reserved.
Interventional Genetic Study Group in Cardiovascular Disease's, National Institute of Cardiology Ignacio Chávez, Mexico City, Mexico.
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